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Angong Niuhuang Pills
Chinese Pharmacopoeia: Angong Niuhuang Pills
Prescription: Bezoar 100g, buffalo horn concentrated powder 200g, musk 25g, pearl 50g, cinnabar 100g, realgar 100g, coptis 100g, scutellaria 100g, gardenia 100g, turmeric 100g, borneol 25g
Properties: Large honey pills with yellow-orange to reddish-brown color; rich aroma and slightly bitter taste.
Processing: For the above eleven ingredients, pearls are water-fed or crushed into very fine powders, cinnabar and realgar are water-fed into very fine powders respectively; coptis chinensis, scutellaria baicalensis, gardenia jasmine and tulip are crushed into fine powders; bezoar, buffalo horn concentrated powder, musk and borneol are finely ground, mixed with the above powders, sieved, mixed, and added with appropriate amount of refined honey to make 600 large honey pills.
Functions and indications: Clearing away heat and detoxification, calming the nerves and opening the mind. Used for fever, evil entering the pericardium, high fever convulsions, coma and delirium.
Usage and dosage Oral, 1 pill at a time, once a day; children under three years old, 1/4 pill at a time, 1/2 pill at a time, once a day for children aged four to six years old; or follow the doctor’s advice.
Note Pregnant women should use with caution.
Specifications Each pill weighs 3g
Storage Sealed.
Excerpt “Chinese Pharmacopoeia”
“Wenbing Tiaobian” Volume 1: Angong Niuhuang Wan
Prescription Bezoar 30g Curcuma 30g Rhinoceros Horn 30g Coptis 30g Cinnabar 30g Plum Tablets 7.5g Musk 7.5g Pearl 15g Gardenia 30g Realgar 30g Scutellaria 30g
Preparation method Grind the above into very fine powder, refine old honey into pills, each pill is 3g, gold foil is used as a coating, and wax is used to protect.
Pharmacological effects 1. Anticonvulsant effect “Chinese Medicine Information” 1989 (106): 2, this prescription can counteract the excitatory effect of amphetamine on mice, significantly delay the onset of pentylenetetrazol-induced clonic seizures in mice, and reduce convulsions and mortality. This indicates that it has an inhibitory effect on the cerebral cortex and a certain protective effect on the vital center. In addition, it also has an anticonvulsant effect of strychnine. 2. Antipyretic effect “Chinese Medicine Information” 1989 (106): 2, this prescription has a significant antipyretic effect on fever caused by bacterial toxins in rabbits, and there is a significant difference compared with the control group one hour after administration.
Functions and indications Clearing away heat and detoxifying, clearing phlegm and opening the orifices. Febrile diseases, heat evil invading the pericardium, phlegm-heat blocking the heart orifices, high fever and irritability, coma and delirium, or tongue lameness and limb numbness, or diarrhea and pulse strength, as well as stroke orifice closure, and convulsions in children are caused by phlegm-heat blocking the heart orifices. It is currently used for patients with phlegm-heat syncope due to Japanese encephalitis, epidemic meningitis, toxic dysentery, uremia, cerebrovascular accident, toxic hepatitis, hepatic coma, etc.
Usage and Dosage Take 1 pill each time. For patients with weak pulse, take it with ginseng soup; for patients with strong pulse, take it with honeysuckle and mint soup. For adults with serious illness and strong body, take two to three pills a day. For children, take half a pill. If they don’t know, take another half pill.
Remarks In the prescription, bezoar clears the heart and detoxifies, clears phlegm and opens the orifices, rhinoceros horn clears the heart, cools blood and detoxifies, and musk opens the orifices and wakes up the mind. These three flavors are the main medicine; coptis chinensis, scutellaria baicalensis, and gardenia clear the heat of the three burners, and realgar clears phlegm, which are all ministerial medicines; turmeric and borneol are aromatic and remove filth, open the orifices and close them, and penetrate the inner envelope. Cinnabar, pearl, and gold foil calm the heart and soothe the nerves, and honey harmonizes the stomach and regulates the middle, which are all adjuvants. All the medicines are used together to clear heat and detoxify, clear phlegm and open the orifices.
Excerpt from Volume 1 of Treatise on Warm Diseases

Teachings on Warm Diseases: Angong Niuhuang Pills

Composition: Bezoar, Curcuma, Rhinoceros Horn (replaced by concentrated powder of buffalo horn), Coptis chinensis, Scutellaria baicalensis, Gardenia jasminoides, Cinnabar, Realgar, 1 liang (30g) each, Plum slices, Musk, 2 qian 5 fen (7.5g) each, Pearl 5 qian (15g), Gold foil coating.

Usage: The above ingredients are ground into very fine powder, refined with old honey to make pills, 1 qian (3g) each, Gold foil as coating, wax as protection. For weak pulse, take with ginseng soup, for strong pulse, take with honeysuckle and mint decoction, take one pill each time. For adults with serious illness and strong body, take twice a day, even three times a day; for children, take half a pill, if they do not feel well, take half a pill again. Modern usage: Replace rhinoceros horn with 30g concentrated powder of buffalo horn. For the above 11 ingredients, pearls are water-beaten or crushed into very fine powders, cinnabar and realgar are water-beaten into very fine powders respectively; coptis root, scutellaria root, gardenia and curcuma are crushed into fine powders; bezoar, concentrated powder of buffalo horn, musk and borneol are finely ground, mixed with the above powders, sieved, mixed, and an appropriate amount of refined honey is added to make large honey pills. Take one pill each time, once a day; children under 3 years old take 1/4 pill once, children aged 4 to 6 years old take 1/2 pill once a day; or follow the doctor’s advice.
Efficacy Clears away heat and opens the orifices, removes phlegm and detoxifies.
Indications Heat evil invading the pericardium. High fever and irritability, coma and delirium, thirst and dry lips, red or purple tongue, rapid pulse, as well as stroke coma and convulsions in children are caused by phlegm and heat in the pericardium.
Explanation of the prescription This syndrome is caused by warm and hot toxic evil invading the pericardium. When pathogenic heat enters the pericardium, it will disturb the mind, so the patient will have a high fever, be irritable, and become delirious. Excessive heat will damage the body fluid, so the patient will feel thirsty and have dry lips. The red tongue and rapid pulse are all signs of excessive heat damaging the body fluid. The treatment should be aromatic and open the orifices, clear the heart and detoxify, and clear phlegm and calm the mind. In the prescription, bezoar is bitter and cool in nature, and is good at clearing the heart and detoxifying, clearing phlegm and opening the orifices; musk passes through the twelve meridians and is good at opening the orifices and clearing the channels, so it is an important medicine for opening the orifices, awakening the mind, and reviving the mind. They are all monarch medicines. Buffalo horn clears the heart, cools the blood, and detoxifies, and calms the nerves; coptis root, scutellaria baicalensis, and gardenia help bezoar clear heat, purge fire, and detoxify; borneol and curcuma aromatically dispel filth, open the orifices, and help musk to open the orifices, and they are all minister medicines. Cinnabar calms the heart and calms the mind; pearls clear the heart and calm the mind to eliminate irritability; realgar clears phlegm and detoxifies, and they are all adjuvant medicines. Honey harmonizes the stomach and regulates the middle, and is a guiding medicine. Gold foil is used as a coating, and its effect of calming the mind is taken. This prescription can clear the heart and purge fire, cool the blood and detoxify, and is combined with aromatic drugs to open the orifices, which is the compatibility characteristic of the cool and open agent.
Clinical application 1. Key points of the prescription This prescription is an important prescription for clearing heat and opening the orifices, with coma and delirium, high fever and irritability, red or purple tongue, and rapid pulse as the key points of syndrome differentiation.
2. Modern application This prescription is often used to treat epidemic encephalitis B, epidemic cerebrospinal meningitis, toxic dysentery, uremia, cerebrovascular accident, hepatic coma, etc., which are caused by phlegm and heat.
3. Precautions for use Pregnant women should use it with caution, and it is forbidden to use it for cold and closed syndrome.
Prescription song Angong Niuhuang Kaiqiao Fang, Qinlianzhi Yuzhu Realgar, Niujiao Zhenzhu Bingshenbao, Rexian Xinbo has good effects.
Extension Angong Niuhuang Wan is the most famous emergency medicine in traditional Chinese medicine. It is mostly used for emergency treatment of stroke, hemiplegia, and pericardial invagination due to febrile diseases. It has been known as “saving emergency cases immediately and saving dying in an instant” since ancient times. It is one of the “three treasures for treating febrile diseases”. However, the dosage form of the ancient prescription is obviously not suitable for the needs of clinical emergencies. Therefore, the dosage form of this prescription has been reformed in modern times. The scarce source of bezoar is replaced by the effective ingredients of bezoar, taurocholic acid and swine bile acid, and the expensive rhinoceros horn and pearl are replaced by buffalo horn and mother-of-pearl. Cinnabar and gold foil are removed, and isatis root is added to enhance the function of clearing heat and detoxifying. Qingkailing injection is developed, which not only retains the unique efficacy of the original prescription, but also increases the clinical indications, changes oral administration to intramuscular injection or intravenous drip, makes the effect rapid, and significantly improves the efficacy. Gong, in ancient times, refers to the site of the emperor, and now refers to the pericardium. According to Chinese medicine, the heart is like a monarch in the human body, occupying a supreme position, and the pericardium is like the palace of the heart, protecting the sacredness of the heart and making it inviolable. If warm and toxic evils attack the heart, the pericardium will stand up and take the evil on behalf of the heart. In the prescription, bezoar is the monarch, which can clear the evil heat of the pericardium. “Angong” is used to describe that after taking the pill, the heart can settle in its palace. Therefore, it is named “Angong Niuhuang Pills”.
Excerpt from “Wenbing Tiaobian”
প্রভাব
Angong Niuhuang Pills are traditional Chinese patent medicines for clearing heat and detoxifying, calming the nerves and opening the orifices. It is used for fever, evil entering the pericardium, high fever convulsions, coma and delirium; stroke coma and encephalitis, meningitis, toxic encephalopathy, cerebral hemorrhage, sepsis with the above symptoms,
Ancient books record:
Wutang: This is a prescription that is aromatic and clears turbidity and benefits all orifices, salty and cold to protect kidney water and calm the heart, and bitter and cold to clear the fire and relieve the heart. The essence of the sun and the moon of bezoar can communicate with the spirit of the heart. Rhino horn is mainly used to treat all kinds of poisons, evil spirits and miasma. Pearls get the essence of Taiyin and communicate with the spirit, and combined with rhino horn, it can replenish water and put out fire. Curcuma is the fragrance of grass, plum wood (according to borneol, it is made by soaking old foreign fir wood, and in recent times, it is made by beating camphor. Camphor can cause fire in water, which is very harmful and must not be used), realgar stone fragrance, musk is the fragrance of essence and blood, and the four fragrances are used together to make the closed evil heat, warm poison deep in the division of Jueyin come out from the inside, and the evil filth will disappear, and the spirit can be restored. Coptis chinensis purges heart fire, Gardenia purges the heart and triple burner fire, Scutellaria purges the gallbladder and lung fire, so that the evil fire is dispersed along with all the fragrances. Cinnabar replenishes the heart body and purges the heart, and gold foil drops phlegm and calms it. Combined with pearls, rhino horn is the commander-in-chief of the battle.
Note: The 1990 edition of the Chinese Pharmacopoeia uses concentrated water buffalo horn powder instead of rhino horn, removes gold, and makes large honey pills.
The prescription is explained as follows:
In the prescription, bezoar clears the heart and cools the liver, clears phlegm and opens the orifices, calms the wind and stops convulsions; water buffalo horn clears the camp and cools the blood, detoxifies and calms the nerves; musk is aromatic and opens the orifices, clears the meridians and wakes up the mind, and is the main medicine. Coptis chinensis, Scutellaria baicalensis, and Gardenia jasminoides clear heat, purges fire and detoxifies, and realgar detoxifies and clears phlegm, and is the minister medicine. Borneol and Curcuma aromatica clear the orifices and wake up the mind, clear turbidity and relieve depression; cinnabar and pearl calm the heart and calm the mind, calm the nerves and stop convulsions, and are the adjuvant medicines. The combination of these medicines has the effect of clearing heat, detoxifying, calming the nerves and opening the orifices.
What diseases can Angong Niuhuang Wan be used to treat?
This product has the effects of clearing heat, detoxifying, calming the nerves and opening the orifices, and can be used to treat high fever and coma seen in coma, stroke, convulsions, craniocerebral injury, severe hepatitis, and pulmonary encephalopathy.
What symptoms can Angong Niuhuang Wan be used to relieve?

Coma: Wind-heat, spring-heat, summer-heat epidemic poison, burning blood, pericardium, wind-moving phlegm, covering the clear orifices, causing high fever and irritability, coma and delirium, phlegm in the throat, spasms and convulsions, macules, vomiting and bleeding, red tongue with scorched fur, and thin and rapid pulse; epidemic cerebrospinal meningitis, Japanese encephalitis, toxic encephalopathy, and sepsis have the above symptoms.

Stroke: Phlegm and fire are excessive inside, liver yang turns into wind, wind and yang carry phlegm, disturbing the mind and causing sudden coma, unconsciousness, two fists clenched, teeth clenched, red face and rough breathing, crooked mouth and tongue, phlegm in the throat, red tongue, yellow and greasy fur, and stringy and slippery pulse; cerebral infarction and cerebral hemorrhage have the above symptoms

Convulsion: Children’s exogenous febrile disease, extreme heat generates wind, and phlegm and heat are excessive inside, blocking the mind. Symptoms include high fever, irritability, headache, cough, phlegm in the throat, coma, delirium, convulsions, red tongue, yellow fur, and stringy pulse; patients with epidemic cerebrospinal meningitis and Japanese encephalitis with the above symptoms.
What drugs are often used with Angong Niuhuang Wan?
The use of Chinese medicine must be based on syndrome differentiation and treatment. It should be used under the guidance of professional Chinese medicine practitioners. It should not be used at will, and it should not be used at will. Chinese medicine prescriptions and advertisements should not be used at will. Please follow the doctor’s advice for combined use of this product.
সতর্কতা
Children, the elderly, and breastfeeding women should consult a doctor for specific medications, and should not be used at will. During the medication period, avoid raw, cold, and greasy foods.
This product contains cinnabar and realgar, which should not be taken in excess or for a long time. It should be used with caution by those with liver and kidney dysfunction.
Those with high fever, coma, stroke, and coma who have difficulty taking this product orally should be given nasogastric administration.
Who is strictly prohibited from using Angong Niuhuang Wan?
· Those who are allergic to this product are prohibited.
It is not suitable for those with cold and coma. .
This product is contraindicated for pregnant women. .
Who needs to use Angong Niuhuang Wan with caution?
·People with impaired liver and kidney function should use it with caution.
·People with allergic constitution should use it with caution.
Athletes should use it with caution. .
Can special groups use Angong Niuhuang Wan?
Pregnant and lactating women: If you are pregnant, planning to become pregnant or are lactating, please inform your doctor in time and consult to choose the best treatment.
·Children: Children should take the medicine under the guidance of a doctor and under the supervision of an adult.
What drugs will Angong Niuhuang Wan interact with?
If this product is used at the same time as other drugs, drug interactions may occur. Therefore, if you are taking other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and treatment plans you are receiving.
ব্যবহার এবং ডোজ
This product is a prescription drug. Please strictly follow the doctor’s prescription and drug instructions. Do not use it at will.
During the medication period, the diet should be light and spicy food should be avoided.
What dosage forms or specifications does Angong Niuhuang Wan have?

Angong Niuhuang Wan, specifications: each pill weighs 3g; each pill weighs 1.5g.

What is the specific use of Angong Niuhuang Wan? Oral medication. 2 pills (1.5g per pill) or 1 pill (3g per pill) at a time, once a day. Please consult your doctor for details. Children under 3 years old take 112 pills (1.5g per pill) or 114 pills (3g per pill) at a time; 4-6 years old take 1 pill (1.5g per pill) or 112 pills (3g per pill) once a day.

Note: Children must take the medicine under the guidance of a doctor and under the supervision of an adult; those who have difficulty taking this product orally due to high fever, coma, stroke, etc. should be given by nasogastric tube.

ব্যবহারের জন্য নির্দেশাবলী
During treatment, if cold limbs, pale face, cold sweat, and weak pulse occur, the drug should be stopped immediately and a doctor should be consulted in time. Angong Niuhuang Wan is used to treat coma, stroke, convulsion, craniocerebral injury, severe hepatitis, and high fever coma seen in pulmonary encephalopathy, all of which are emergency and critical care. When using Angong Niuhuang Wan, you should seek medical treatment as soon as possible for comprehensive treatment.
It is forbidden to take it when the properties of the drug change. Please keep this product out of reach of children.
How long does it usually take for Angong Niuhuang Wan to take effect after using it?
Because the severity of each person’s condition and the degree of drug absorption are different, the specific time it takes to take Angong Niuhuang Wan to take effect will also be different.
If the patient’s condition is relatively mild and the drug absorption is relatively good, it may take 3 days to see the effect. Some patients may have a more serious condition and poor drug absorption, and it may take longer to see the effect, so it is necessary to judge according to the specific situation of the patient.
When taking the drug, you must follow the doctor’s instructions and take it according to the dosage. You must not take the drug blindly without permission to avoid adverse effects on your health.
What should I do if I overdose on Angong Niuhuang Wan?
The use of drugs needs to follow a certain dosage. When the user uses a drug that exceeds this dosage, it is called drug overdose.
When using Angong Niuhuang Wan, you should follow the instructions for use or follow the doctor’s advice; children or patients without behavioral capacity should use it under adult supervision to avoid overdose.
This product contains cinnabar and realgar, which should not be taken in excess or for a long time; excessive use may cause cumulative poisoning, mercury toxic nephropathy or allergies, and you should seek medical attention as soon as possible.
What are the adverse reactions of Angong Niuhuang Wan?
Improper use of this product can cause hypothermia: there are also reports of mercury toxic nephropathy or allergies after medication. If you feel any discomfort during medication, please consult a doctor in time. The doctor will judge whether to stop the medication or take necessary measures according to the severity of the adverse reaction.
Under what circumstances should you stop using Angong Niuhuang Wan immediately?
If you experience cold limbs, pale complexion, constant cold sweat, and weak pulse during treatment, you should stop taking the medicine immediately.
Under what circumstances do you need to go to the hospital as soon as possible?
In addition to the above adverse reactions, you may have other side effects. If you feel unwell after taking the medicine, please seek medical attention in time