Suanzaoren – Ziziphi Spinosae

Suanzaoren – Ziziphi Spinosae Ziziphus jujuba seed
[Medicinal use] This product is the mature seed of Ziziphus jujuba, a plant of the Rhamnaceae family.
[Nature and flavor and meridians] Sweet, sour, flat. Enters the heart, spleen, liver, and gallbladder meridians.
[Effects] Nourishes the heart and calms the mind, nourishes yin and astringes sweat.
[Clinical application] 1. Used for symptoms such as insomnia due to deficiency and restlessness, palpitations and restlessness.
Ziziphus jujuba seed nourishes yin and blood, benefits the heart and liver, and calms the mind. It is mainly used for symptoms such as palpitations and insomnia caused by blood deficiency and inability to nourish the heart or virtual fire inflammation. It is often used together with Poria cocos, cypress seeds, salvia miltiorrhiza, and Rehmannia glutinosa.
2. Used for sweating.
Ziziphus jujuba seed has the function of astringing and stopping sweating. It can be used together with oysters and floating wheat to treat sweating.
[Prescription name] Fried jujube seeds (fried until slightly burnt, crushed when used), raw jujube seeds (raw, crushed when used)
[General dosage and usage] Three to five coins, decocted. Recently, clinical use of jujube seeds is to grind them into powder or grind them into pills, and swallow five fen each time. If used to treat insomnia, it can be swallowed before going to bed.
[Comments] 1. Ziziphus jujuba seed tastes sour and has a flat nature. It nourishes the heart and liver and is an important medicine for treating insomnia due to deficiency. In addition to the Ziziphus jujuba seed soup in the “Golden Chamber” of the Han Dynasty, which uses this product as the main medicine, the Guipi Decoction in the “Jisheng Fang” of the Song Dynasty also uses Ziziphus jujuba seed in combination with ginseng, astragalus, white atractylodes, angelica, longan meat and other qi-nourishing and blood-nourishing medicines to treat qi and blood deficiency, heart and spleen deficiency, palpitations and insomnia, fatigue and sweating.
2. The predecessors said that “cooked use can treat insomnia, and raw use can treat good sleep”. After clinical practice, this product has a good sedative and hypnotic effect whether used raw or fried, and has no adverse effects when used to treat insomnia.
[Example of prescription] Ziziphus jujuba seed soup “Golden Chamber”: Ziziphus jujuba seed, licorice, Anemarrhena asphodeloides, Poria cocos, Chuanxiong. Treats insomnia due to deficiency and night sweats.
This product is the dried seeds of Ziziphus jujuba Mi.var.spinosa, a plant of the Rhamnaceae family.

(Bunge)Hu ex H.F.Chou’s dried mature seeds. The mature fruits are harvested in late autumn and early winter, and the pulp and shell are removed.

[Propiedades]
This product is oblate or oblate oval, 5-9mm long, 5-7mm wide, and about 3mm thick. The surface is purple-red or purple-brown, smooth and shiny, some with cracks, some with round protrusions on both sides; some with flat surfaces, with a raised longitudinal line in the middle; the other side is slightly raised. One end is concave, with a linear hilum visible; the other end has a small protruding chalazion. The seed coat is brittle, the endosperm is white, and there are 2 cotyledons, which are light yellow and oily. The smell is slight and the taste is light.

[Identificación]
(1) This product is pinkish brown. The palisade cells of the seed coat are brownish red, polygonal in surface view, about 15um in diameter, with thick walls, lignified, and small cell cavity; they are long strips in side view, with thickened outer walls, thicker upper and middle parts of the side walls, and gradually thinner lower parts; they are polygonal or rounded polygonal in bottom view. The epidermal cells of the seed coat are brownish yellow, rectangular or square in surface view, with thickened and lignified walls in a beaded manner. The epidermal cells of the cotyledons contain small clusters and prismatic crystals of calcium oxalate.
(2) Take 1g of the powder of this product, add 30ml of methanol, heat and reflux for 1 hour, filter, evaporate the filtrate, and add 0.5ml of methanol to the residue to dissolve it as the test solution. Take the reference substance of jujube seed saponin A and the reference substance of jujube seed saponin B, add methanol to make a mixed solution containing 1mg of each per 1ml, as the reference substance solution. According to the thin layer chromatography method (general rule 0502), 5u of each of the above two solutions are taken and spotted on the latter tridacna G thin layer plate, and water-saturated n-butanol is used as the developing agent. Develop, take out, dry, spray with 1% vanillin sulfuric acid solution, and immediately inspect. In the chromatogram of the test sample, spots of the same color appear at the corresponding position of the chromatogram of the reference sample.
(3) Take 19 of the powder of this product, add 30ml of petroleum ether (60~90℃), heat and reflux for 2 hours, filter, discard the petroleum ether liquid, evaporate the residue, add 30ml of methanol, heat and reflux for 1 hour, filter, evaporate the filtrate, and dissolve the residue in 2ml of methanol to prepare the test solution. Take 1g of the reference medicinal material of Ziziphus jujuba seed and prepare the reference medicinal material solution in the same way. Take the reference substance of spinosum and add methanol to prepare a solution containing 0.5mg per 1ml as the reference solution. According to the thin layer chromatography method (General Rule 0502), take 2 of each of the above three solutions and spot them on the same silica gel G thin layer plate, use water-saturated n-butanol as the developing agent, develop, take out, dry, spray with 1% vanillin sulfuric acid solution, and inspect under ultraviolet light (365nm). In the chromatogram of the test sample, the same blue fluorescent spots appear at the corresponding positions of the chromatogram of the reference medicinal material and the chromatogram of the reference sample.
[Inspección]
Impurities (core-shell, etc.) shall not exceed 5% (General Rule 2301)
Water content shall not exceed 9.0% (General Rule 0832 Method 2).
Total ash shall not exceed 7.0% (General Rule 2302). Heavy metals and harmful elements are determined according to the lead, cadmium, arsenic, mercury and copper determination method (General Rule 2321 atomic absorption spectrophotometry or inductively coupled plasma mass spectrometry). Lead shall not exceed 5mg/kg; cadmium shall not exceed 1mg/kg; arsenic shall not exceed 2mg/kg; mercury shall not exceed 0.2mg/kg; copper shall not exceed 20mg/kg.
Aflatoxin is determined according to the fungal toxin determination method (General Rule 2351)
Take about 5g of the powder of this product (passed through a No. 2 sieve), accurately weigh, add 3g of sodium chloride, and determine and calculate according to the preparation method of the test sample under the aflatoxin determination method. The total amount of aflatoxin B per 1000g of this product shall not exceed 5ug, and the total amount of aflatoxin G2, aflatoxin G1, aflatoxin B, and aflatoxin B shall not exceed 10ug.
[Determinación del contenido]
Jujube saponin A is determined according to high performance liquid chromatography (General Rule 0512).
Chromatographic conditions and system suitability test: Octadecanane bonded silica gel was used as filler; acetonitrile was used as mobile phase A and water was used as mobile phase B; gradient elution was performed according to the provisions in the following table; evaporative light scattering detector was used for detection. The theoretical plate number should be no less than 2000 based on the peak of jujube saponin A.

Preparation of reference solution: Take an appropriate amount of jujube saponin A reference substance, weigh it accurately, and add methanol to make a solution containing 0.1 mg per 1 ml.
Preparation of test solution Take about 1g of the powder (passed through No. 4 sieve), weigh accurately, put it in a Soxhlet extractor, add an appropriate amount of petroleum ether (60~90℃), heat and reflux for 4 hours, discard the petroleum ether liquid, evaporate the solvent from the residue, transfer it to a conical flask, add 20ml of 70% ethanol, heat and reflux for 2 hours, filter, wash the residue with 5ml of 70% ethanol, combine the washing liquid and the filtrate, recover the solvent to dryness, dissolve the residue in methanol, transfer it to a 5ml volumetric flask, add methanol to the scale, shake, filter, and take the filtrate to obtain
Determination method Accurately aspirate 5μ1, 20u of the reference solution and 10μl of the test solution, inject them into the liquid chromatograph, determine, and calculate using the external standard two-point method logarithmic equation to obtain.
This product, calculated on the basis of dry product, contains no less than 0.030% of jujube saponin A (C58Hg4026).
Spinosin is determined according to the high performance liquid chromatography method (General Rule 0512).
Chromatographic conditions and system suitability test: Octadecyl brick ane bonded tridacnamate is used as filler: acetonitrile is used as mobile phase A, water is used as mobile phase B, and gradient elution is performed according to the provisions in the following table: the detection wavelength is 335nm. The number of theoretical plates calculated based on the spinoside peak should not be less than 2000.
Preparation of reference solution: Take an appropriate amount of spinoside reference, accurately weigh it, and add methanol to make a solution containing 0.2mg per 1ml.
Preparation of test solution: Take the test solution under the item of [Content determination] Jujube saponin A as the test solution.
Determination method: Accurately aspirate 10ml of reference solution and test solution respectively, inject them into the liquid chromatograph, and determine them.
This product, calculated on the basis of dry product, shall contain not less than 0.080% of spinoside (C28H32015).
Medicinal pieces
[Tratamiento]
Remove the remaining shell from the sour jujube kernel. Crush it when used.
[Propiedades]
[Identificación]
[Inspección]
(Moisture and total ash)
[Determinación del contenido]
Lo mismo que el material medicinal.
Fried sour jujube kernels Take the clean sour jujube kernels and stir-fry them according to the stir-frying method (General Rule 0213) until they swell and the color becomes slightly darker. Crush it when used.
[Propiedades]
This product is shaped like sour jujube kernels. The surface is slightly swollen and has slight burnt spots. It has a slight burnt aroma and a light taste.
[Inspección]
Moisture: Same as the medicinal material, not more than 7.0%.
Total ash: Same as the medicinal material, not more than 4.0%.
[Identificación]
Content determination]
Lo mismo que el material medicinal.
[Naturaleza y sabor y meridianos)
Sweet, sour, flat. It enters the liver, gallbladder, and heart meridians.
[Funciones e indicaciones]
Nourishes the heart and liver, calms the mind and calms the nerves, restrains sweating, and produces body fluids. It is used for insomnia due to deficiency, nightmares, excessive sweating due to physical weakness, and thirst due to loss of body fluids.
【Uso y dosificación】
10~159.
【Almacenamiento】
Place in a cool and dry place to prevent moth.
Where are the main production areas of sour jujube kernels?
It is mainly produced in Liaoning, Hebei, Shanxi, Inner Mongolia, and Shaanxi.
Where are the main medicinal parts of sour jujube kernels?
Medicinal parts of sour jujube kernels:
This product is the dried mature seeds of the rhamnaceae plant sour jujube. Harvest the mature fruits in late autumn and early winter, remove the pulp and shell, collect the seeds, and dry them. Characteristics of the medicinal parts of sour jujube kernels:
This product is oblate or oblate oval, 5~9mm long, 5~7mm wide, and about 3mm thick. The surface is purple-red or purple-brown, smooth and shiny, and some have cracks.
Some have round protrusions on both sides; some have a relatively flat side with a raised longitudinal line in the middle; the other side is slightly raised. One end is concave, and a linear hilum can be seen; the other end has a small protruding chalazion.
The seed coat is brittle, the endosperm is white, and the cotyledons are 2, light yellow, and rich in oil. The smell is slight and the taste is light.
How are the seeds of the Chinese jujube recorded in ancient books?
“Ben Jing”: “It is used to treat cold and heat in the heart and abdomen, evil qi accumulation, soreness and pain in the limbs, and dampness. Long-term use can calm the five internal organs, lighten the body and prolong life.
“Famous Doctors’ Records”: “It is used to treat restlessness and insomnia, pain above and below the navel, long-term blood circulation, sweating and thirst, nourishing the middle, benefiting the liver qi, strengthening the tendons and bones, helping the yin qi, and making people fat and healthy.
“Compendium of Materia Medica”: “If you sleep a lot, eat it raw: if you can’t sleep, fry it.
“Compendium of Materia Medica·Volume 36”: “The fruit of the Chinese jujube is sour and astringent, so it is used to treat liver disease, cold and heat qi accumulation, sour and astringent diarrhea, and fullness and pain below the navel. Its kernel is sweet and moist, so it is used to treat gallbladder deficiency and insomnia, thirst and sweating.
Effects and Functions
The seeds of the Chinese jujube have the effects of nourishing the heart and liver, calming the mind, astringing sweat, and promoting body fluid.
What are the main effects and clinical applications of Chinese date seeds?
Chinese date seeds are used for insomnia due to deficiency, palpitations and dreams, excessive sweating due to physical weakness, and thirst due to loss of body fluids.
Restless syndrome
· Treats insomnia due to deficiency of heart and liver yin and blood, palpitations and dreams, etc., can be used alone, or used with Ophiopogon japonicus, processed Polygonum multiflorum, Poria cocos, etc.
· Treats insomnia due to deficiency of liver deficiency and heat, can be used with Anemarrhena asphodeloides, Poria cocos, Chuanxiong, etc.
· Treats insomnia due to palpitations due to deficiency of heart and spleen, often used with Astragalus, Angelica sinensis, Codonopsis pilosula, etc.
Excessive sweating due to physical weakness, thirst due to loss of body fluids
· Treats sweating due to physical weakness, often used with Astragalus, Schisandra chinensis, Cornus officinalis, etc.
· Treats thirst due to loss of body fluids, can be used with Rehmannia glutinosa, Ophiopogon japonicus, Radix Trichosanthis, etc.
What other effects does sour jujube seed have?
In my country’s traditional food culture, some Chinese medicinal materials are often widely consumed as food ingredients among the people, that is, materials that are both food and Chinese medicinal materials according to tradition. According to the documents issued by the National Health Commission and the State Administration for Market Regulation, sour jujube seeds can be used (instant edible medicinal substances) within the limited scope of use and dosage. As both medicine and food.
The commonly used medicinal diet recipes for sour jujube seeds are as follows:
Palpitations, palpitations, insomnia (heart and liver blood deficiency type)
1 pig heart, 15g Poria, 15g sour jujube seeds, 6g Polygala, cut the pig heart open, wash it, and put it in a casserole; then put the washed and broken jujube seeds, Poria, and Polygala into the pot, add appropriate amount of water, first boil it with high heat, remove the floating foam, and then simmer it with low heat until the pig heart is cooked. Eat the pig heart and soup, and add a little salt to taste when eating.
Heart and liver deficiency, restlessness and insomnia
10g sour jujube seeds, 10g Rehmannia glutinosa, 30~60g polished rice. Stir-fry the Chinese date seeds, crush them, and decoct them with Rehmannia glutinosa to obtain the juice. Then use the juice to cook porridge, 3 times a day.
What are the compound preparations containing Chinese date seeds?
Chinese date seeds soup
Nourishes blood and calms the mind, clears heat and relieves restlessness. Indications: Liver blood deficiency and internal disturbance of deficiency heat. Deficiency and restlessness, insomnia, restlessness, dizziness, dry throat and mouth, red tongue, and stringy and thin pulse.
Chinese date seeds and calming the mind capsule
Nourishes blood and calms the mind. Used for insomnia, forgetfulness, restlessness, and dizziness caused by insufficient heart blood; neurasthenia with the above symptoms
Guipi pills
Yinqi and spleen, nourishing blood and calming the mind. Used for deficiency of both heart and spleen, shortness of breath and palpitations, insomnia and dreaminess, dizziness, fatigue, loss of appetite, metrorrhagia and bloody stools.
Tianwang Buxin Dan nourishes yin and clears heat, nourishes blood and calms the mind. Indications: Yin deficiency and blood deficiency, restlessness. Palpitations, insomnia, fatigue, forgetfulness, or nocturnal emission, hot hands and feet, sores in the mouth and tongue, dry stool, red tongue with little coating, and thin pulse.
Guipi Decoction
Replenishes qi and blood, strengthens the spleen and nourishes the heart. Indications: deficiency of both qi and blood in the heart, spleen and blood, and spleen failure to regulate blood.
Modern research progress on Chinese jujube seeds
This product has a variety of pharmacological effects such as sedation and hypnosis, anti-depression, anticonvulsant, memory improvement, and anti-myocardial ischemia.
Uso
It has the effect of promoting body fluid. It can be taken with more decoction, or boiled in water, porridge or soaked in wine. However, no matter which method is used, Chinese jujube seeds have the effects of nourishing the heart and liver, calming the mind and calming the nerves, and astringing sweat, it needs to be taken according to the doctor’s instructions.
How to use Chinese jujube seeds correctly?
When Chinese jujube seeds are decoctioned for oral administration, the usual dosage is 10~15g; it can also be ground into powder and swallowed before going to bed, 1~1.5g each time.
Chinese herbal medicine slices such as Chinese jujube seeds and fried Chinese jujube seeds can be produced by different processing methods. Raw use is cool in nature, suitable for those with yin deficiency, insomnia and heat symptoms. Stir-fried use is warm in nature, suitable for those with palpitations, poor appetite and excessive sweating due to deficiency of both heart and spleen. Different processing methods have different effects, but the method of use is the same. Please follow the doctor’s advice for specific use.
Ziziphus jujuba seeds are generally used in decoctions, decocted and taken, and can also be made into powders or pills for consumption. However, the use of Chinese medicinal materials must be treated according to syndrome differentiation and should be used under the guidance of professional Chinese medicine practitioners. They should not be used at will, and should not be used at will, let alone listen to Chinese medicine prescriptions and advertisements at will.
In addition, Ziziphus jujuba seeds can also be used for daily health care. Common methods of consumption are as follows:
Cook porridge (ziziphus jujuba seeds porridge): 10g Ziziphus jujuba seeds, 15g Rehmannia glutinosa, 100g glutinous rice. Ziziphus jujuba seeds and Rehmannia glutinosa are decocted in water to obtain the medicinal juice, and then added to glutinous rice to cook porridge for consumption. It is used for insufficient heart yin, irritability and fever, palpitations and insomnia.
Soaking in wine: Soaking in wine with Chinese medicines such as Chinese jujube seeds and codonopsis, astragalus, and longan meat can nourish qi and blood, and nourish the spleen and blood.
How to prepare sour jujube seeds?
Sour jujube seeds
Take the original medicinal materials, remove impurities and hard shells, wash and dry. Crush when used. Stir-fried jujube seeds
Take the clean jujube seeds, put them in a stir-frying container, heat them over a low fire, stir-fry until they swell, there is a popping sound, the color becomes slightly darker, take them out and cool them. Crush when used.
What drugs should be used with sour jujube seeds at the same time with special attention?
The combined use of Chinese medicine and the combined use of Chinese and Western medicines require syndrome differentiation and treatment, and clinical individualized treatment. If you are using other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and the treatment plan you are receiving
Instructions for use of medicine
Sour jujube seeds are sour and astringent, so those with solid evil and depressed fire should be cautious when taking them.
What precautions should be taken when using sour jujube seeds?
Sour jujube seeds are moist and slippery. People with loose stools should not take a large amount of single medicine.
Ziziphus jujuba seeds are sweet and slow invigorating, and are good at treating insomnia caused by deficiency of blood in the heart and liver, and lack of rest. Insomnia caused by phlegm, food stagnation, or liver depression and fire should not be taken in large quantities.
During medication, be careful not to eat cold, raw and cold foods, spicy and greasy foods. Pregnant and lactating women: If you are pregnant, planning to be pregnant, or are lactating, please inform your doctor in time and consult whether Chinese medicine can be used for treatment.
· Children: Children’s medication must be carried out under the guidance of a doctor and adult supervision.
· Guarde adecuadamente los materiales medicinales y no entregue sus propios materiales medicinales a otras personas.
How to identify and use Ziziphus jujuba seeds?
Ziziphus jujuba seeds are sweet, sour, and flat in nature. They are in the heart, liver, and gallbladder meridians. They have the functions of nourishing the liver, calming the heart, calming the mind, and astringing sweat.
Raw Ziziphus jujuba seeds and fried Ziziphus jujuba seeds have basically the same functions, both of which have the functions of calming the mind and calming the mind Use.
. The raw product is flat in nature and is suitable for inclusion in clearing agents. It has the effects of nourishing the heart and calming the mind, nourishing the liver and kidneys. It is used for insomnia, palpitations, dizziness, tinnitus, and blurred vision caused by insufficient heart yin or liver and kidney deficiency and liver and gallbladder heat.
Fried jujube seeds are warm and tonic in nature and are suitable for inclusion in warming agents. They are good at nourishing the heart and restraining sweating. It is used for palpitations, forgetfulness, sweating, spontaneous sweating, and insomnia caused by insufficient qi and blood. Ziziphus jujuba.
The kernel is crispy after frying, which is conducive to decocting the effective ingredients and improving the efficacy.
The most frequently asked question by patients
How to eat Ziziphus jujuba seeds to treat insomnia most effectively?
Ziziphus jujuba seeds can be used in combination with traditional Chinese medicine as a Chinese medicine decoction, or as a medicinal diet, so as to achieve the effect of treating insomnia. Medicinal recipe: 1 pig heart, 15g of Poria, 15g of Ziziphus jujuba seeds, 6g of Polygala tenuifolia. Cut the pig heart open, wash it, and put it in a casserole. Then put the washed and broken Ziziphus jujuba seeds, Poria, and Polygala tenuifolia into the pot, add an appropriate amount of water, boil it with high heat first, remove the floating foam, and then simmer it with low heat until the pig heart is cooked. Eat the pig heart and soup, and add a little salt to taste when eating. It is suitable for palpitations, restlessness, and insomnia (heart and liver blood deficiency type).
Ziziphus jujuba seeds with longan meat: Ziziphus jujuba seeds are sweet, sour and flat, which can replenish yin and blood and calm the mind; longan meat is sweet, warm and moist, which can not only nourish the spleen and nourish the heart and improve intelligence, but also replenish blood, calm the mind and calm the mind. The two medicines are used together, and the power of nourishing the heart and spleen, nourishing blood and nourishing, calming the mind and improving intelligence is doubled. It is suitable for excessive thinking, fatigue of the heart and spleen, sallow complexion, palpitations, restlessness, forgetfulness, insomnia, dreaminess and easy startle, etc.
What are the effects and functions of stir-fried Chinese jujube kernels?
Chinese jujube kernels are sweet, sour and flat in nature. They are in the heart, liver and gallbladder meridians. They have the functions of nourishing the liver, calming the mind, soothing the nerves and astringing sweat.
Stir-fried Chinese jujube kernels are warm and tonic in nature, suitable for warming agents, and are good at nourishing the heart and astringing sweat. They are used for palpitations, forgetfulness, night sweats, spontaneous sweating, and insomnia caused by insufficient qi and blood.
After stir-frying, Chinese jujube kernels are crispy, which is conducive to decocting effective ingredients and improving the efficacy.
What are the effects of Chinese jujube kernel, lily and poria tea?
Chinese jujube kernels have the effects of nourishing the heart and liver, soothing the nerves and astringing sweat. Lily has the effects of nourishing yin and moistening the lungs, clearing the heart and soothing the nerves. Poria has the effects of diuresis, swelling, moisture penetration, and strengthening the spleen and calming the heart.
The combination of the three can effectively relieve the symptoms of insomnia in patients and significantly improve the quality of sleep in patients.
Chinese jujube kernel, lily and poria tea can calm the nerves and soothe the nerves, and can also effectively relieve symptoms such as headaches, depression, chest tightness and shortness of breath.
What are the effects of compound sour jujube seed tablets?

Compound sour jujube seed tablets:

·It is composed of 250g sour jujube seed (fried), 83g gardenia, 167g polygala, 83g licorice, 167g poria, and 83g Liushenqu. The above 6 ingredients are made into 1000 tablets, each tablet is equivalent to 0.83g of the original medicinal materials, and is coated with sugar.

·It can relieve restlessness and calm the mind.

·It is used for neurasthenia, insomnia, dreaminess, easy fright, fatigue, etc. Oral administration, 4 to 6 tablets each time, 3 times a day.