Psoralea corylifolia – Bu Gu Zhi

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[Family and medicinal part] This product is the mature fruit of the leguminous plant Psoralea corylifolia.
[Nature and flavor and meridians] Pungent, bitter, very warm. Enters the spleen and kidney meridians.
[Effects] Tonify the kidney and assist yang.
[Clinical application] 1. Used for lower deficiency and cold, impotence, spermatorrhea, premature ejaculation, waist pain, frequent urination, enuresis and other symptoms.
Psoralea corylifolia has the function of warming and tonifying kidney yang. It is used for kidney yang deficiency, impotence, spermatorrhea, frequent urination, enuresis and other symptoms. It is often used in combination with Xianlingpi, Cuscuta chinensis, etc.; for waist pain, it is often used in combination with Chuanduan, Gouji, etc.
2. Used for cold diarrhea.
Psoralea corylifolia can replenish the fire of the gate of life and warm the spleen yang, treat cold diarrhea, and is often used with nutmeg, etc.
3. Used for asthma.
Insufficient kidney qi and poor absorption often cause shortness of breath. This product warms the kidney and absorbs qi and relieves asthma. It is often used with walnut meat to treat asthma due to deficiency and cold.
[Prescription name] Psoralea corylifolia, Psoralea corylifolia (fry with salt water until slightly charred before use.)
[General dosage and usage] 2 to 4 qian, decocted and taken orally.
[Comment] Psoralea corylifolia is a commonly used yang-enhancing drug in clinical practice. It can nourish the kidney, consolidate essence and reduce urine, warm and move spleen yang to stop diarrhea, and can nourish the kidney, absorb qi and relieve asthma. It is not suitable for those with yin deficiency, excessive fire and constipation.
[Example of prescription] Pishen Pills (formerly known as Ershen Pills) “Benshi Fang”: Psoralea corylifolia, nutmeg. Treat spleen and kidney yang deficiency and diarrhea at dawn.
【Literature Excerpt】《Compendium of Materia Medica》: “It can treat back pain, cold knees, dampness in the bladder, expel cold numbness, stop urination, and relieve coldness in the abdomen.”

《Compendium of Materia Medica》: “It can treat kidney diarrhea and open the gate of life.”

《Compendium of Materia Medica》: “It can strengthen the yang energy, reduce urination, treat cold knee pain, and relieve diarrhea caused by kidney deficiency.”

This product is the dried mature fruit of the leguminous plant Psoralea corylifoliaL. When the fruit is ripe in autumn, the fruit sequence is harvested, dried, rubbed out, and impurities are removed.

【Propiedades】
This product is kidney-shaped, slightly flat, 3-5mm long, 2-4mm wide, and about 1.5mm thick. The surface is black, dark brown or gray-brown with fine reticular wrinkles. The top is rounded and blunt, with a small protrusion, and there is a fruit stalk mark on the concave side. It is hard. The pericarp is thin and difficult to separate from the seed; there is 1 seed and 2 cotyledons, which are yellow-white and oily. It has a fragrant smell and tastes spicy and slightly bitter.

【Identificación】
(1) This product is grayish yellow in powder form. The palisade cells of the seed coat have longitudinal grooves when viewed from the side, and one brilliant band is located near the upper edge. The top surface is polygonal, the cell cavity is extremely small, the pore groove is fine, and the bottom surface is round and fish-shaped. The cell cavity contains reddish-brown substances. The supporting cells are dumbbell-shaped when viewed from the side and circular when viewed from the surface. The endometrial glands (endophytic glands) are mostly broken, and the intact ones are circular, consisting of dozens to dozens of cells that are longitudinally extended and radially arranged. The calcium oxalate columnar crystals are small and exist in the mesocarp cells in sheets.
(2) Take 0.5g of the powder of this product, add 20ml of ethyl acetate, ultrasonically treat for 15 minutes, filter, evaporate the filtrate, and add 1ml of ethyl acetate to dissolve the residue as the test solution. Take the psoralen reference substance and isopsoralen reference substance separately, add ethyl acetate to make a mixed solution containing 2mg of each per 1ml, and use it as the reference solution. According to the thin layer chromatography method (General Rule 0502), 2.44 l of each of the above two solutions were taken and spotted on the same silica gel G thin layer plate, and developed with n-hexane-ethyl acetate (4:1) as the developing agent, taken out, dried, sprayed with 10% potassium hydroxide methanol solution, and inspected under ultraviolet light (365nm). In the chromatogram of the test sample, the same two light spots appeared at the corresponding positions of the chromatogram of the reference sample.
[Inspección]
Impurities shall not exceed 5% (General Rule 2301).
Water content: not more than 9.0% (General Rule 0832, Method 2)
Not more than 8.0% (General Rule 2302) Total ash content: not more than 2.0% (General Rule 2302)
[Content determination]: Determined by high performance liquid chromatography (General Rule 0512)
Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel as filler; methanol-water (55:45) as mobile phase; detection wavelength is 246nm. The theoretical plate number calculated based on the psoralen peak should not be less than 3000.
Preparation of reference solution: Take appropriate amount of psoralen reference substance and isopsoralen reference substance, weigh accurately, and add methanol to make solutions containing 20ug of each per 1ml. Preparation of test solution Take about 0.5g of the powder (passed through No. 3 sieve), weigh accurately, put it in a Soxhlet extractor, add an appropriate amount of methanol, heat and reflux for extraction for 2 hours, cool, transfer to a 100ml volumetric flask, add methanol to the scale, shake well, filter, and take the filtrate.
Accurately aspirate 5~10u of the reference solution and the test solution respectively, inject into the liquid chromatograph, and determine. Determination method This product is calculated on the basis of dry product, and the total amount of psoralen (C1H6O3) and isopsoralen (C1H6O3) shall not be less than 0.70%.
Pieza de decocción
[Tratamiento]
Psoralea corylifolia Remove impurities.
[Properties][Identification][Inspection]
(Water content Total ash Acid insoluble ash)
[Determinación del contenido]
Lo mismo que los materiales medicinales.
Salted Psoralea corylifolia Take clean Psoralea corylifolia and stir-fry it according to the salt roasting method (General Rule 0213) until it is slightly swollen.
【Propiedades】
This product is shaped like psoralea corylifolia. The surface is black or dark brown, slightly bulging. It has a slight fragrance and tastes slightly salty.
Where is the main production area of ​​psoralea corylifolia?
It is mainly produced in Henan, Sichuan, Anhui, and Shaanxi.
Where is the main medicinal part of psoralea corylifolia?
Medicinal parts of psoralea corylifolia:
This product is the dried mature fruit of the leguminous plant Psoralea corylifolia L. When the fruit is ripe in autumn, the fruit sequence is harvested, dried, and the fruit is rubbed out to remove impurities.
Characteristics of the medicinal parts of psoralea corylifolia:
This product is kidney-shaped, slightly flat, 3~5mm long, 2~4mm wide, and about 1.5mm thick. The surface is black, dark brown or gray-brown, with fine reticular wrinkles. The top is round and blunt, with a small protrusion, and there are fruit stalk marks on the concave side, and the texture is hard. The pericarp is thin and difficult to separate from the seeds. There is 1 seed and 2 cotyledons, which are yellow-white and oily. It has a fragrant smell and tastes spicy and slightly bitter.
How is Psoralea corylifolia recorded in ancient books?
“Compendium of Materia Medica”: “It can treat men’s back pain, cold knees, scrotal dampness, expel all kinds of cold numbness, stop urination and coldness in the abdomen,
“Kaibao Materia Medica”: “It can treat five kinds of labor and seven kinds of injuries, wind deficiency and coldness, bone marrow damage and failure, kidney cold and semen flow, and women’s blood and qi abortion.

Efectos
Psoralea corylifolia has the effects of warming the kidney and assisting yang, consolidating semen and reducing urine, absorbing qi and calming asthma, warming the spleen and stopping diarrhea; it can be used externally to eliminate wind and remove spots.

What are the main effects and clinical applications of Psoralea corylifolia?
Psoralea corylifolia is used for kidney yang deficiency, impotence and spermatorrhea, enuresis and frequent urination, cold pain in the waist and knees, asthma caused by kidney deficiency, and diarrhea at dawn; it can be used externally to treat vitiligo and alopecia areata.

Síndrome de deficiencia de yang de riñón
·It can treat kidney deficiency and impotence, and is often used together with walnut meat, dodder seed, agarwood, etc.

·It can treat kidney qi deficiency and coldness, spermatorrhea and frequent urination, etc., and can be used together with fennel.
· Treat kidney deficiency, waist and knee pain and weakness, etc., and can be used with Eucommia ulmoides, walnut meat, Achyranthes bidentata, etc.
Kidney deficiency with asthma
Treat asthma caused by kidney yang deficiency and kidney failure to absorb qi, often used with aconite, cinnamon, Rehmannia glutinosa, etc.
Five-o’clock diarrhea
Treat spleen and kidney yang deficiency, chronic diarrhea or five-o’clock diarrhea, often used with Evodia rutaecarpa, nutmeg, Schisandra chinensis
What other effects does Psoralea corylifolia have?
In my country’s traditional food culture, some Chinese medicinal materials are often widely consumed as food ingredients by the people, that is, substances that are both food and Chinese medicinal materials according to tradition (i.e. edible drug substances). According to the documents issued by the National Health Commission and the State Administration for Market Regulation, Psoralea corylifolia can be used as both medicine and food within a limited range of use and dosage.
Common medicinal diet recipes for Psoralea corylifolia are as follows
Lumbar pain during pregnancy:
60g of Psoralea corylifolia, stir-fry until fragrant. Chew half a walnut meat first, and take 6g with warm wine on an empty stomach.
Impotence, spermatorrhea, premature ejaculation, frequent urination, cold pain in waist and knees, chronic cough and asthma:
·300g of psoralea corylifolia, 600g of walnut meat, 300g of honey.
·Pound the walnut meat into a paste; mix with psoralea corylifolia wine, steam, dry, and grind into powder. Melt and boil the honey, add walnut paste and psoralea corylifolia powder, mix well and serve.
Pain caused by weakness in waist and ribs:
·20g of psoralea corylifolia, 30g of walnut meat, 8g of dog spine (dehaired), 6g of fennel (fried with salt), 2 pieces of pig and sheep kidneys each, 1 grapefruit·Grind the first 4 herbs into powder, slice the kidneys, mix with an appropriate amount of salt, and remove the core of the grapefruit. Then put the medicine and the slices of kidneys into the cored grapefruit shell, simmer over fire, and eat the kidneys.
What are the compound preparations containing psoralea corylifolia?
Qing’e Pills
Tonify the kidney and strengthen the waist. Used for kidney deficiency and low back pain, difficulty in sitting up, and weak knees.
Gushen Dingchuan Pills
Warms the kidney to absorb qi, strengthens the spleen and resolves phlegm. It is used for cough, asthma, especially when moving, caused by lung and spleen deficiency and kidney failure to absorb qi; chronic bronchitis, emphysema, bronchial asthma with the above symptoms.
Sishen Pills
Warms the kidney to dispel cold, astringes the intestines to stop diarrhea. It is used for diarrhea caused by insufficient kidney yang, with symptoms such as intestinal rumbling, abdominal distension, loose stools, poor digestion, chronic diarrhea, yellow face and cold limbs
Bu Gu Zhi Pills
Treats impotence due to excessive sexual desire, heavy hands and feet, night sweats, long-term cold organs, waist and knee pain, spleen and stomach weakness
Modern research progress on Bu Gu Zhi
This product has multiple pharmacological effects such as sex hormone-like, regulating intestinal motility, enhancing immunity, promoting osteoblast proliferation, anti-prostate hyperplasia, and relieving asthma.
Uso
Bu Gu Zhi uses Bu Gu Zhi decoction pieces, which can be taken orally or externally. Please follow the doctor’s advice for specific medication.
How to use Psoralea corylifolia correctly?
When taking decoction of Psoralea corylifolia orally, the usual dosage is 6~10g.
For external use: appropriate amount, it can be made into 20%~30% tincture and applied to the affected area to treat vitiligo and alopecia areata. Psoralea corylifolia is generally used in decoctions, decoctions and can also be made into powders or pills. However, the use of Chinese medicinal materials must be treated according to syndrome differentiation and should be used under the guidance of professional Chinese medicine practitioners. It should not be used at will, and it should not be used at will, let alone listen to Chinese medicine prescriptions and advertisements. In addition, Psoralea corylifolia can also be soaked in wine, and it can be mixed with Chinese medicines such as Codonopsis pilosula and Rehmannia glutinosa to soak in wine, which has the effects of nourishing blood and producing essence, strengthening muscles and bones, and consolidating the foundation and preserving the essence.
How to prepare Psoralea corylifolia?
Psoralea corylifolia
Remove impurities. Take the original medicinal materials!
Salt Psoralea corylifolia
Take clean Psoralea corylifolia, add salt water and mix well, and soak until the salt water is absorbed. Put it in a frying container and heat it over a low fire. When it bulges slightly, cracks and emits fragrance, take it out and let it cool. For every 100kg of Psoralea corylifolia, use 2kg of salt.
What drugs should be used with Psoralea corylifolia with special attention?
The combined use of Chinese medicine and Chinese and Western medicine requires syndrome differentiation and treatment, clinical individualized treatment,
Si está usando otros medicamentos, consulte a un médico antes de tomar el medicamento e infórmele sobre todas las enfermedades diagnosticadas y el plan de tratamiento que está recibiendo.
Instrucciones de medicación
Psoralea corylifolia is warm and dry, which can easily hurt yin and help fire, so people with yin deficiency, internal heat and constipation should not take it.
What are the precautions when using Psoralea corylifolia?
People with yin deficiency, fire and constipation should not take it. .
During the medication period, you should pay attention to avoid eating cold, raw and cold foods, spicy and greasy foods, and avoid smoking and drinking.
Pregnant and lactating women: If you are pregnant, planning to become pregnant or are lactating, please inform your doctor in time and consult whether Chinese medicine can be used for treatment.
Niños: La medicación en niños debe realizarse bajo guía de un médico y supervisión de un adulto.
Guarde adecuadamente los materiales medicinales y no entregue sus propios materiales medicinales a otras personas.
Evite utilizar utensilios de cobre o hierro para decoctar medicamentos.
Las preguntas más frecuentes de los pacientes
How to make Bu Gu Zhi Hu Zhi Decoction
[Ingredients] Bu Gu Zhi 100g, walnut meat 200g, honey 100g.
[Preparation and Usage] Mix Bu Gu Zhi with wine, steam, dry, and grind into powder; mash the walnut meat into a paste. Melt the honey and boil it, add the walnut paste and Bu Gu Zhi powder, and mix well.
Store in a bottle, take 10g each time, mix with rice wine, and take with boiled water for those who are not good at drinking. Twice a day.
[Effects] Warm kidney yang, strengthen tendons and bones, and stop asthma and cough. Indications and Applications] Kidney yang deficiency syndrome. Suitable for kidney yang deficiency, impotence and premature ejaculation, spermatorrhea and frequent urination, cold pain in the waist and knees, long-term cough and asthma, etc. [Precautions for use] Do not use it for cough and asthma caused by phlegm and fire, and asthma caused by lung and kidney yin deficiency.
Effects and Functions of Salt Bu Gu Zhi Functions and Indications
Bu Gu Zhi is pungent, bitter, and warm in nature. It enters the kidney and spleen meridians. It has the effects of warming the kidney and strengthening yang, removing dampness and relieving itching. Salt roasting can alleviate the warm and dry nature, and can lead the medicine into the kidney, enhancing the effect of tonifying the kidney and absorbing qi. It is used for impotence and spermatorrhea, enuresis and frequent urination, cold pain in the waist and knees, asthma caused by kidney deficiency, and diarrhea at dawn.