Ban Lan Gen – Isatis Root

Isatis root (with: isatis leaf, indigo)
[Medicinal use] This product is the root of the cruciferous plant Isatis indigotica.
[Nature and flavor and meridians] Bitter, very cold. Enters the heart and stomach meridians.
[Effects] Clears heat and detoxifies, cools blood.
[Clinical application] 1. Used for seasonal fever, heat entering the blood, high fever coma and heat toxicity spots.
Heat entering the blood will cause coma and spots. Isatis leaf clears heat, cools blood and detoxifies, so it is often used as a key drug in clinical practice, often used with coptis root, gardenia, red peony root, moutan bark, and cimicifuga.
2. Used for erysipelas, sore throat, mouth sores, swelling and toxicity.
Heart and stomach real fire inflammation will cause sore throat and mouth sores. Heat toxicity dissipates in the skin, causing erysipelas, sores, carbuncles and hot boils. Isatis indigo leaf can relieve heat and toxins in the heart and stomach, and is often used in combination with Scrophularia, Gypsum, Coptis, Gardenia, Isatis root, etc. for the above symptoms.
[Prescription name] Isatis indigo leaf (wash, dry, and chop)
[General dosage and usage] Three to five coins, one liang can be used for large doses. Decoction.
[Additional medicine] 1. Isatis root: The root of Isatis indigo is used in Shanghai. It has a bitter and cold nature. It has the effects of cooling blood, detoxifying, and clearing the throat. It is often used clinically for big head plague, heat toxic rash, sore throat, etc., and its function is similar to that of Isatis indigo leaf; in recent years, it has also been used clinically to treat infectious hepatitis. Usage and dosage are the same as Isatis indigo leaf.
2. Indigo: After adding water to fresh Isatis indigo leaf and smashing it, add lime water, etc., and take the indigo powder floating on the surface. After drying, it is Indigo. The nature, taste, and efficacy are the same as Isatis indigo leaf. For external use, it can be used to treat stomatitis, tonsillitis, etc.; for internal use, it can be used to treat lung heat cough; the general dosage is 3 to 5 fen, which can be taken in pills or powders, or mixed with other medicines for decoction. For external use, it is appropriate.
[Comments] 1. Daqingye has the function of clearing heat and cooling blood. It is an important detoxification medicine. It is mainly used for heat toxic spots, erysipelas, sore throat, mouth sores, sores, carbuncle and swelling, so the predecessors believed that it can relieve heart and stomach heat toxicity. In recent years, this medicine has been widely used in clinical practice. In addition to being used to treat the above symptoms, it can also be used for phlegm heat in the lungs and yellow and thick sputum; it is especially commonly used for epidemic encephalitis B. It can be used alone for prevention, and can also be combined with bupleurum, honeysuckle, forsythia, isatis root, Scrophularia, and Rehmannia. It can clear the heat toxicity of qi and nutrient, and can be used to treat various types of encephalitis B, and the heat type is more suitable.
2. There are many varieties of Daqingye sold in the market all over the country, and the plant sources are different, and they are: Acanthaceae plant Malan. Cruciferae plants Isatis indigo and Daqing. Polygonum indigofolia of the Polygonaceae family. Indigofera indigofolia of the Leguminosae family. The leaves of the above plants are all used as Daqingye and can also be used as raw materials for making indigo. Except for Indigofera indigofolia, their roots are all used as Radix Isatidis.
3. Daqingye planted in Shanghai in recent years is the leaf of Isatis indigotica, a herbaceous plant of the Cruciferae family. Clinical practice has shown that it has good heat-clearing and detoxifying effects. However, although this taste is not very bitter, it is turbid and cold in nature. If used in excessive amounts, it can easily cause nausea and vomiting.
[Example of prescription] Daqing Decoction “Shenshi Zunsheng”: Daqing, Scrophularia, Anemarrhena, Gardenia, Gypsum, Akebia, Cimicifuga, Platycodon. Treats internal heat and toxicity.
Rhinoceros Horn Daqing Decoction “The Book of Living People”: Daqing, Rhinoceros Horn, Douchi, Gardenia. Treats typhoid fever, sore throat.
Dig in autumn, remove mud and sand, and dry in the sun. This product is the dried root of Isatis indigotica Fort. of the Cruciferae family.
【プロパティ】
This product is cylindrical, slightly twisted, 10~20cm long, 0.5~1cm in diameter. The surface is light grayish yellow or light brownish yellow, with longitudinal wrinkles, horizontal long lenticel-like protrusions and rootlet marks. The root head is slightly swollen, and dark green or dark brown petiole residues arranged in a whorl and dense warty protrusions can be seen. The body is solid, slightly soft, the cross section of the cortex is yellowish white, and the wood is yellow. The smell is slight, and the taste is slightly sweet and then bitter.
【識別】
(1) Cross section of this product: The cork layer is composed of several rows of cells. The inner cork layer is narrow. The phloem is broad and the rays are obvious. The cambium is annular. The xylem vessels are yellow, sub-circular, and about 80um in diameter; there are wood fiber bundles.
The thin-walled cells contain starch granules.
(2) Take 0.5g of this product powder, add 20ml of dilute ethanol, ultrasonically treat for 20 minutes, filter, evaporate the filtrate to dryness, and add 1ml of dilute ethanol to dissolve the residue as the test solution. Take another 0.5g of Radix Isatidis reference medicinal material and prepare a reference medicinal material solution in the same manner. Take another arginine reference substance and add dilute ethanol to prepare a solution containing 0.5mg per 1ml as the reference substance solution. According to the thin layer chromatography method (General Rule 0502), absorb the above three solutions for 1~2 hours respectively, and spot them on the same silica gel G thin layer plate, use n-butanol-glacial acetic acid-water (19:5:5) as the developing agent, develop, take out, blow dry with hot air, spray with ninhydrin test solution, and heat at 105℃ until the spots are clearly colored. In the chromatogram of the test sample, spots of the same color appear at the corresponding positions of the chromatogram of the reference medicinal material and the chromatogram of the reference substance.
(3) Take 1g of this product powder, add 20ml of 80% methanol, ultrasonically treat for 30 minutes, filter, evaporate the filtrate, add 1ml of methanol to the residue to dissolve it, and use it as the test solution. Take another 1g of Radix Isatidis reference medicinal material and prepare a reference medicinal material solution in the same manner. Take (R, S)-gaoyichun reference substance, add methanol to make a solution containing 0.5mg per 1ml as the reference substance solution. According to the thin layer chromatography method (General Rule 0502), take 5~10μ1 of each of the above three solutions and spot them on the same silica gel GF54 thin layer plate, use petroleum ether (60~90℃)-ethyl acetate (1:1) as the developing agent, develop, take out, dry, and inspect under ultraviolet light (254nm). In the chromatogram of the test sample, spots of the same color appear at the corresponding positions of the chromatogram of the reference medicinal material and the chromatogram of the reference substance.
[検査]
The moisture content shall not exceed 15.0% (General Rule 0832 Method 2)
The total ash content shall not exceed 9.0% (General Rule 2302).
The acid-insoluble ash content shall not exceed 2.0% (General Rule 2302)
[抽出する]
Determine by hot soaking method under the alcohol-soluble extract determination method (General Rule 2201), using 45% ethanol as solvent, and shall not be less than 25.0%.
【内容決定】
Determine by high performance liquid chromatography (General Rule 0512)
Chromatographic conditions and system suitability test Use octadecyl alkane bonded pyridine as filler: methanol-0.02% phosphoric acid solution (7:93) as mobile phase: detection wavelength is 245nm. The theoretical plate number calculated by (R, S)-pyridine peak should not be less than 5000.
Preparation of reference solution Take an appropriate amount of (R, S)-pyridine reference substance, accurately weigh it, and add methanol to make a solution containing 40ug per 1ml. Preparation of test solution Take about 1g of the powder (passed through a No. 4 sieve), weigh accurately, place in a round-bottom bottle, accurately add 50ml of water, weigh, decoct for 2 hours, cool, weigh again, make up the lost weight with water, shake well, filter, and take the filtrate.
Determination method Accurately aspirate 10~20ml of the reference solution and the test solution respectively, inject into the liquid chromatograph, and determine.
This product contains (R, S)-goitrin (C5H7NOS) not less than 0.020% calculated on the basis of dry product.
煎じ薬
[処理]
Remove impurities, wash, moisten, cut into thick slices, and dry.
[プロパティ]
This product is a round thick slice. The outer skin is light grayish yellow to light brownish yellow with longitudinal wrinkles. The cut surface is yellowish white in the cortex and yellow in the wood. Slight smell, slightly sweet and bitter
[Inspection)
Water content Same as the medicinal material, not more than 13.0%.
Total ash Same as the medicinal material, not more than 8.0%.
[Content determination] Same as the medicinal material, containing (R, S)-goitrin (C5H7NOS) shall not be less than 0.030%
[Identification] (Except for cross-section)
[Inspection] (Acid-insoluble ash)
[Extract] Same as the medicinal material.
[Nature and flavor and meridians] Bitter, cold. Entrance to the heart and stomach meridians.
[Functions and indications] Clears away heat and detoxifies, cools blood and relieves sore throat. Used for warm epidemics, fever and sore throat, warm toxic spots, mumps, sore throat, big head plague, erysipelas, carbuncle. [Usage and dosage] 9~15g.
[Storage] Place in a dry place to prevent mildew and moth.
Where is the main production area of ​​Isatis root?
It is mainly produced in Jiangsu and Hebei. Where is the main part of Isatis indigotica used as medicine?

Medicinal part of Isatis indigotica:
Isatis indigotica is the dried root of Isatis indigotica Fort., a plant of the Cruciferae family. It is harvested in autumn, sand is removed, and it is dried in the sun.

Characteristics of the medicinal part of Isatis indigotica:
This product is cylindrical, slightly twisted, 10~20cm long, and 0.5~1cm in diameter. The surface is light grayish yellow or light yellow, with longitudinal wrinkles, horizontal long lenticel-like protrusions and root branch marks.

The root head is slightly swollen, and dark green or dark brown petiole residues arranged in a wheel shape and dense wart-like protrusions can be seen. The body is solid, the texture is slightly soft, the cross-section is yellowish-white in the cortex, and the wood is yellow. The smell is slight, and the taste is slightly sweet and bitter.
How is the root of isatis recorded in ancient books?
“Rihuazi Bencao”: “Treats the heat and poison of heaven.” (Quoted from “Bencao Shu”)
“Bencao Bian Du”: “Cools blood, clears heat, detoxifies, prevents epidemics, and kills insects.
“Classification of Herbal Medicines”: “Relieves all kinds of poisons and malignant sores, disperses poisons and removes fire, mashes juice, or takes or applies.
効果
Isatis has the effects of clearing heat and detoxifying, cooling blood and relieving sore throat.
What are the main effects and clinical applications of isatis?
Isatis is used for warm epidemics, fever and sore throat, warm toxic spots, mumps, sore throat, red sha, big head plague, erysipelas, carbuncle.
Exogenous epidemics, fever due to febrile diseases
· Treat fever and sore throat due to exogenous wind-heat and heat toxicity, often used with Isatis indigo leaf, Forsythia suspensa, and Polygonum aviculare
· Treat heat in the qi, severe fever and thirst, often used with Gypsum, Rhizoma Anemarrhenae, etc.;
· Treat fever due to both qi and blood burning, or high fever and rashes due to heat entering the blood, often used with Lithospermum officinale, Radix Rehmanniae, Scrophulariae, etc.
Painful cheeks and throat paralysis, erysipelas and carbuncle
Treat sore throat, dry oropharynx, and cheek swelling due to heat toxicity, can be used alone:.
Throat discomfort, erysipelas, mumps, etc., often used with Burdock seeds, Forsythia suspensa, Scrophulariae, etc. Treat big head plague, red and swollen head and face,
What are the compound preparations containing Isatis root?
Puji Disinfection Drink
Clears heat and detoxifies, dispels wind and dispels evil. Mainly treats big head plague. Chills and fever, red and swollen head and face, eyes can not open, throat discomfort, dry tongue and thirst.
Shenxidan
Clears heat and opens the orifices, cools blood and detoxifies. Indications: warm summer heat epidemic, evil into the blood syndrome. High fever, purple macules, oropharyngeal erosion, red eyes and irritability, purple tongue
Isatis root granules
Clears heat and detoxifies, cools blood and relieves throat. Used for sore throat, dry oropharynx, and swollen cheeks caused by excessive heat in the lungs and stomach; acute tonsillitis and mumps with the above symptoms.
Cold and fever granules
Clears heat and detoxifies, dispels wind and relieves the symptoms. Used for upper respiratory tract infection, acute tonsillitis, pharyngitis, which are exogenous wind-heat and heat-toxic congestion syndrome, with symptoms of fever and sore throat.
Modern research progress on Isatis root
This product has multiple pharmacological effects such as antibacterial, antiviral, anti-endotoxin, antipyretic, and anti-inflammatory.
使用方法
Isatis root has the effects of clearing heat and detoxifying, cooling blood and relieving throat. Generally, isatis root slices are used for internal use. Please follow the doctor’s instructions for specific medication.
How to use isatis root correctly?
When isatis root decoction is taken internally, the common dosage is 9~159.
When isatis root is used externally, take an appropriate amount of isatis root decoction to apply to the affected area, or take an appropriate amount of fresh isatis root and crush it to extract juice.
Isatis root is generally used in decoctions, decoctions are taken, and can also be made into powders or pills for consumption. However, the use of Chinese medicinal materials must be treated according to syndrome differentiation and should be used under the guidance of professional Chinese medicine practitioners. It should not be used at will, and it should not be used at will, let alone listen to Chinese medicine prescriptions and advertisements at will. In addition, isatis root can also be used for daily health care. Common methods of consumption are as follows:
Soaking in water: Soaking isatis root in water can relieve symptoms such as sore throat, but it cannot be drunk for a long time. .
Note: People with weak constitutions should determine the dosage and time under the guidance of a doctor when taking it, and never take the medicine on their own.
How to prepare isatis root?
Clean and remove impurities, moisten thoroughly, slice, and dry.
What drugs should be used with Isatis root at the same time?
The combined use of Chinese medicine and Chinese and Western medicine requires syndrome differentiation and clinical individualized treatment. If you are using other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and the treatment plan you are receiving.
使用方法
Isatis root is bitter and cold, so people with spleen and stomach deficiency should take it with caution.
What precautions should be taken when using Isatis root?
People with spleen and stomach deficiency should use it with caution, and people with weak body but no real fire, heat and poison should not use it.
·During the medication period, be careful not to eat cold, raw and cold food, spicy and greasy food.
Pregnant and lactating women: If you are pregnant, planning to become pregnant or are lactating, please inform your doctor in time and consult whether Chinese medicine can be used for treatment.
·子供：子供の投薬は医師の指導と大人の監督の下で行う必要があります。
Please properly store the medicinal materials and do not give your own medicinal materials to others.
薬に関するヒント
患者様から最もよく聞かれる質問
What is the difference between Daqingye and Banlangen?
Daqingye and Banlangen are basically from the same source and have similar effects. They both have the effects of clearing heat and detoxifying, cooling blood and removing spots.
However, Daqingye has strong cooling blood and removing spots, while Banlangen has strong detoxification, throat-clearing and knot-dispersing effects.
Can I get the COVID-19 vaccine after drinking Banlangen granules?
It is recommended not to get the vaccine immediately.
If the patient has a cold, pharyngitis and other diseases, the COVID-19 vaccine can be given after the symptoms disappear and the medication is stopped for 2 to 3 days. If there are no symptoms and the Banlangen is taken only to prevent a cold, the COVID-19 vaccine can be given two days later. It is recommended to keep warm and add or remove clothes in time to prevent a cold.
Please consult a doctor for details.
Can pregnant women drink Banlangen granules?
You can drink Banlangen granules during pregnancy.
Bailangen has the effects of clearing heat and detoxifying, antibacterial and anti-inflammatory, and antiviral.
If pregnant women have colds, pharyngitis, and upper respiratory tract infections, they can drink Isatis Root Granules in moderation under the guidance of a doctor.
Effects and functions of Isatis Root Granules
Isatis Root Granules are composed of Isatis Root.
It has the effects of clearing away heat and detoxifying, cooling blood and relieving sore throat.
It is used for sore throat and dryness of the oropharynx caused by excessive heat in the lungs and stomach: acute tonsillitis with the above symptoms.