Sophora flavescens – ku shen

Sophora flavescens
[Medicinal use] This product is the root of the leguminous plant Sophora flavescens.
[Nature and flavor and meridians] Bitter, cold. Enters the heart, liver, small intestine, large intestine, and stomach meridians.
[Effects] Clears heat and dries dampness, dispels wind and kills insects.
[Clinical application] 1. Used for damp-heat diarrhea, jaundice, leucorrhea, genital itching, etc.
Sophora flavescens can clear dampness and heat, and can guide dampness and heat to penetrate into the lower orifices, so it is suitable for the above-mentioned symptoms, and is often used in combination with Phellodendron chinense, Gentiana scabra, etc.
2. Used for wind itching, scabies, stubborn ringworms, leprosy, etc.
Sophora flavescens can dispel wind and dampness, and can kill insects. It is used for wind itching, scabies, stubborn ringworms, and is often used in combination with red peony root, rehmannia root, white moss peel, etc.; for leprosy, it is often used in combination with Radix Paeoniae Rubrae, etc.
In addition, this product can clear heat and dysentery, and can be used for symptoms of internal dampness and heat and difficulty in urination.
[Prescription name] Sophora flavescens, Sophora flavescens slices (wash, dry, slice for use)
【一般的な用法・用量】1～3銭を煎じて服用します。
[Comment] Sophora flavescens has the effect of clearing heat and treating dysentery, which is similar to that of Coptis chinensis; it is also similar to Phellodendron chinense and Gentiana scabra in removing damp heat from the lower part of the body. But it can also dispel wind, kill insects and relieve itching, and can be used to treat skin eczema, itching and other symptoms, which is the specialty of Sophora flavescens.
[Example of prescription] Zhili San “Medical Insight”: Sophora flavescens, Pueraria root, Red Peony Root, Mountain Slag, Tangerine Peel, Malt, Chen Songluo Tea. Treat dysentery.
Sophora flavescens San “Zhengzhi Zhunsheng”: Sophora flavescens, Salvia miltiorrhiza, Cnidium monnieri. Treat all scabies and wind itching, which can cause sores.
This product is the dried root of Sophora flavescens Ait., a plant of the Leguminosae family. It is dug in spring and February, the root head and small branch roots are removed, washed and dried, or sliced ​​and dried while fresh. F
[プロパティ]
This product is long cylindrical, often with branches at the bottom, 10~30cm long, 1~6.5cm in diameter. The surface is gray-brown or brown-yellow, with longitudinal wrinkles and long horizontal lenticel-like protrusions. The outer skin is thin, often cracked and curled, easy to peel off, and the peeling part is yellow and smooth. It is hard and not easy to break. The cross section is fibrous; the slice thickness is 3~6mm; the cross section is yellow-white, with radial texture and cracks, and some have atypical vascular bundles in concentric rings or irregularly scattered. The smell is slight and the taste is extremely bitter.
[識別]
(1) The powder of this product is light yellow. The cork cells are light brown, flat and rectangular in cross section, and the wall is slightly curved: the surface view is polygonal, with irregular fine cracks on the surface of the flat wall, and pits on the vertical wall in a broken shape. Fibers and crystal fibers, mostly in bundles; fibers are slender, 11~27um in diameter, thick wall, non-lignified; cells around fiber bundles contain calcium oxalate crystals, forming crystal fibers, and the walls of crystal-containing cells are unevenly thickened. Calcium oxalate crystals are bipyramidal, ginger-shaped or polyhedral, with a diameter of about 23pm. Starch granules, single grains are round or oblong, 2~20um in diameter, with a crack-like umbilicus, and the large grains are faintly visible: there are many complex grains, consisting of 2~12 sub-granules.
(2) Take a cross-section of this product and add a few drops of sodium hydroxide solution. The cork will turn orange-red, gradually turn to blood red, and will not disappear after a long time. The wood does not show color reaction.
(3) Take 0.5g of this product powder, add 0.3ml of concentrated ammonia solution and 2ml of chloroform 5m|, let it stand overnight, filter, evaporate the filtrate, add 0.5ml of chloroform to the residue to dissolve it, and use it as the test solution. Take matrine reference substance and sophoridine reference substance, add ethanol to make a mixed solution containing 0.2mg of each per 1m|, and use it as the reference solution. According to the thin layer chromatography method (General Rule 0502), take 4ul of each of the above two solutions and spot them on the same silica gel G thin layer plate prepared with 2% sodium hydroxide solution, use toluene-acetone-methanol (8:3:0.5) as the developing solvent, and Open, spread 8cm, take out, dry, and then use toluene-ethyl acetate-methanol-water (2:4:2:1) placed below 10℃ as the upper layer solution as the developing agent, develop, take out, dry, and spray with potassium bismuth iodide test solution and sodium nitrite ethanol test solution in sequence. In the chromatogram of the test sample, the same orange spot appears at the corresponding position of the chromatogram of the reference sample.
(4) Take the oxymatrine reference sample and add ethanol to make a solution containing 0.2mg per 1ml as the reference solution. According to the thin layer chromatography method (General Principle 0502 ) test, absorb 4u of the test solution and the above-mentioned reference solution under (identification) (3), and spot them on the same Tridacna G thin layer plate prepared with 2% sodium hydroxide solution, use chloroform-methanol-concentrated ammonia test solution (5:0.6:0.3) placed below 10℃ as the developing agent, develop, take out, dry, and spray with potassium bismuth iodide test solution and sodium nitrite ethanol test solution in turn. In the chromatogram of the test sample, the same orange spot appears at the corresponding position of the chromatogram of the reference sample.
【検査】
Water content Not more than 11.0% (General Rule 0832, second method)
Total ash content shall not exceed 8.0% (General Rule 2302).
[抽出する]
Determine by cold leaching method under water-soluble extract determination method (General Rule 2201), not less than 20.0%
【内容決定】
Determine by high performance liquid chromatography (General Rule 0512).
Chromatographic conditions and system suitability test Use octadecylsilane bonded silica gel as filler; acetonitrile-[0.01mol ammonium acetate solution (concentrated ammonia test solution adjusted to pH 8.1)] (3:2) as mobile phase A, 0.01mol ammonium acetate solution (concentrated ammonia test solution adjusted to pH 8.1) as mobile phase B, and perform gradient elution according to the provisions in the following table: the detection wavelength is 225nm, and the number of theoretical plates calculated based on the oxymatrine peak should be not less than 4000.
Preparation of reference solution Take appropriate amount of matrine reference substance and oxymatrine reference substance, weigh them accurately, add ethanol to make solutions containing 50u9 of matrine and 0.15mg of oxymatrine per ml, and obtain.
Preparation of test solution Take about 0.3g of the powder of this product (passed through No. 3 sieve), weigh it accurately, put it in a stoppered conical bottle, add 0.4ml of concentrated ammonia test solution, accurately add 25ml of chloroform, seal it, weigh the weight, ultrasonically treat (power 250W, frequency 33kHz) for 40 minutes, cool it, weigh it again, make up the lost weight with chloroform, shake it well, filter it, accurately measure 10ml of the filtrate, recover the solvent to dryness, add appropriate amount of anhydrous ethanol to dissolve the residue, transfer it to a 10ml volumetric bottle, add anhydrous ethanol to the scale, shake it, and obtain.
Determination method Accurately aspirate 5μ of each of the above two reference solution and 5~10μ of the test solution, inject them into the liquid chromatograph, and determine, and obtain.
The total amount of matrine (C15H24N20) and oxymatrine (C15H24N202) in this product, calculated on the basis of dry product, shall not be less than 1.2%.
煎じ薬
[処理]
Remove the remaining root heads, separate the large and small ones, wash, soak until about 60% through, moisten thoroughly, cut into thick slices, and dry.
[プロパティ]
This product is in the form of thick slices of quasi-circular or irregular shapes. The outer skin is gray-brown or brownish yellow, and sometimes horizontal long lenticel-like protrusions can be seen. The outer skin is thin, often cracked, curled or falling off, and the falling part is yellow or brownish yellow. The smooth cut surface is yellow-white, fibrous, with radial texture and cracks, and some can see concentric ring patterns. The smell is slight and the taste is extremely bitter.
【内容決定】
The total amount of matrine (C15H24N20) and oxymatrine (C15H24N20,) in the same medicinal material shall not be less than 1.0%
[Identification][Inspection][Extract]
Same medicinal material. 【Nature and flavor and meridians】
Bitter, cold. Enters the heart, liver, stomach, large intestine, and bladder meridians.
【Functions and indications】
Clears heat and dries dampness, kills insects, and is a diuretic. Used for heat dysentery, blood in stool, jaundice, urine retention, leucorrhea, vaginal swelling and itching, eczema, wet sores, skin itching, scabies and leprosy; external treatment of trichomoniasis vaginitis 【Usage and dosage】
4.5~9g. Apply externally in appropriate amount, decoct and wash the affected area.
【Note】
It should not be used with Veratrum.
【ストレージ】
Put in a dry place.
Where is the main origin of Sophora flavescens?
Ecological environment: Grown in sandy land or sunny hillside grass and streams.
Resource distribution: Distributed throughout the country.
Where is the main medicinal part of Sophora flavescens?
Medicinal part of Sophora flavescens:
This product is the dried root of Sophora flavescens, a plant of the Leguminosae family. Dig it up in spring and autumn, remove the root head and small branch roots, wash it, dry it, or slice it while it is fresh and dry it. Characteristics of the medicinal parts of Sophora flavescens: This product is long cylindrical, often branched at the bottom, 10~30cm long, 1~6.5cm in diameter. The surface is gray-brown or brown-yellow, with longitudinal wrinkles and long horizontal lenticel-like protrusions, the outer skin is thin, often cracked and curled, easy to peel off, the peeling part is yellow, smooth, hard, not easy to break, and the cross section is fibrous; the slice thickness is 3~6mm; the cut surface is yellow-white, with radial texture and cracks, and some have heteromorphic vascular bundles in concentric rings or irregularly scattered. The smell is slight and the taste is extremely bitter. How are Sophora flavescens recorded in ancient books?

《本经》: “It is used to treat qi stagnation in the heart and abdomen, accumulation of symptoms and fatigue, jaundice, residual urine, expel water, eliminate carbuncle, tonify the middle, improve eyesight, and stop tears.

《名医别录》: “It benefits the liver and gallbladder, calms the five internal organs, stabilizes the mind and improves the essence, benefits the nine orifices, eliminates latent heat and intestinal wandering, quenches thirst, sobers up, makes urine yellow and red, calms the stomach, and makes people eat more.

《滇南本草》: “It cools blood, eliminates heat and toxins, scabies, pus nests and sores. It treats skin itching, blood wind ringworm sores, naughty white scales, intestinal wind bleeding, and bloody stools. It eliminates wind, swelling and toxins, and phlegm toxins.

《本草求真》: “It clears heat, removes dampness and kills insects.

効果
Sophora flavescens has the effects of clearing heat and dampness, killing insects, and diuresis.
What are the main effects and clinical applications of Sophora flavescens?
Sophora flavescens is used for dry heat dysentery, blood in stool, jaundice and urine retention, red and white vaginal discharge, swelling and itching of the genitals, rashes, sores, itchy skin, ringworm and leprosy: external treatment of trichomoniasis vaginitis.
湿熱症候群
· Treat damp-heat diarrhea, can be used alone, or with white peony root and costus root.
Treat damp-heat jaundice, can be used with gentian, ox bile, etc. .
Treat hemorrhoids caused by damp-heat in the large intestine, blood in stool, often used with Phellodendron, borneol, etc.
Leucorrhea and itching of the genitals, eczema and scabies
· Treat excessive leucorrhea and itching of the genitals caused by damp-heat, often used with Phellodendron, Smilax glabra, etc.
Treat wet sores and eczema, can be used alone, or with Phellodendron and Cnidium monnieri decoction for external washing. .
· Treat scabies and itching of the skin, can be used with Schizonepeta tenuifolia
Difficult urination, burning and astringent pain
It can be used alone or with stone wormwood, plantain seed, gardenia, etc. to treat difficult urination and burning and astringent pain caused by damp-heat accumulation. It can be used alone or with stone wormwood, plantain seed, gardenia, etc.
What other effects does Sophora flavescens have?
The commonly used medicinal diet recipes of Sophora flavescens are as follows:
·For cough, heart pain, watery diarrhea, swelling, edema, and men with thin muscles and weak breath, cough gradually turning into tuberculosis, etc.:
·120g each of Atractylodes macrocephala and oyster (burned), 90g of Sophora flavescens.
·Grind into fine powder, boil 1 pig stomach, grind into paste, and rub into pills as big as sycamore.
·Take 30 or 40 pills each time, three or four times a day.
Note: The use of Chinese medicinal materials must be based on syndrome differentiation and treatment, and should be used under the guidance of professional Chinese medicine practitioners. Do not use them at will, and do not listen to Chinese medicine prescriptions and advertisements at will.
What are the compound preparations containing Sophora flavescens?
Libiling Tablets
Clear heat, remove dampness, and stop diarrhea. Used for dysentery and diarrhea caused by damp-heat in the large intestine, with symptoms of fever, abdominal pain, bloody stool, and tenesmus.
Xiaofengsan
Dispels wind and dampness, clears heat and nourishes blood. Indications: rubella and eczema. Itchy skin, red rash, or cloud-like spots all over the body, oozing fluid after scratching.
Huazhi Suppository
Clears heat and dampness, astringes and stops bleeding. Used for internal and external hemorrhoids and mixed hemorrhoids caused by damp-heat in the large intestine.
Fuyankang Tablets
Clears heat and dampness, regulates qi and activates blood circulation, disperses knots and reduces swelling. Used for leucorrhea caused by damp-heat, toxicity and blood stasis, with symptoms of heavy leucorrhea, yellow color, odor, lower abdominal pain, lumbar pain, bitter mouth and dry throat; patients with the above symptoms in patients with vaginitis and chronic pelvic inflammatory disease.
Kushen Pills
Clears damp-heat, promotes qi and removes blood stasis. Indications: menstrual desire and abdominal pain.
Modern research progress on Sophora flavescens
This product has multiple pharmacological effects such as antipyretic, anti-inflammatory, anti-pathogenic microorganisms, anti-allergic, anti-gastric ulcer, anti-tumor, anti-arrhythmic and myocardial ischemia, antidiarrhea, etc.
Usage method
Sophora flavescens has the effects of clearing heat and dampness, killing insects, and diuresis. Generally, Sophora flavescens slices are used for internal and external use.
How to use Sophora flavescens correctly?
When Sophora flavescens decoction is taken orally, the common dosage is 3~10g.
When Sophora flavescens is used externally, take an appropriate amount of Sophora flavescens decoction water and wash the affected area again: or apply Sophora flavescens powder to the affected area. Sophora flavescens can be processed by different processing methods to produce Chinese medicinal materials such as Sophora flavescens and Sophora flavescens charcoal for the treatment of ringworm, skin itching, etc. Different processing methods have different effects, but the method of use is the same. Please follow the doctor’s advice for specific medication.
Sophora flavescens is generally used in decoctions, decoctions are taken, and can also be made into powders or pills for consumption. However, the use of Chinese herbal medicines must be treated according to the syndrome differentiation and should be used under the guidance of professional Chinese medicine practitioners. Do not use them at will, and do not listen to Chinese medicine prescriptions and advertisements at will.
How to prepare Sophora flavescens?
Sophora flavescens
Take the original herbal medicine, remove impurities and residual roots, wash, soak, moisten, cut into thick slices, and dry. Remove debris.
Sophora flavescens charcoal
Take clean Sophora flavescens slices, put them in a frying container, heat them with high heat, fry until the surface is burnt black and the inside is burnt yellow, take them out, and dry them.
Which drugs should be used with Sophora flavescens at the same time?
It should not be used with Veratrum.
The combined use of Chinese medicine and Chinese and Western medicine requires syndrome differentiation and clinical individualized treatment.
If you are using other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and treatment plans you are receiving.
投薬指示
Sophora flavescens is bitter and cold, so people with spleen and stomach deficiency should not take it.
What precautions should be taken when using Sophora flavescens?
Sophora flavescens is anti-Veratrum, and it should not be used with Veratrum.
The combined use of Chinese medicine and Chinese and Western medicine requires syndrome differentiation and clinical individualized treatment.
If you are using other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and treatment plans you are receiving.
投薬指示
Sophora flavescens is bitter and cold, so people with spleen and stomach deficiency and cold should not take it.
What precautions should be taken when using Sophora flavescens?
Sophora flavescens is opposite to Veratrum, and should not be used with Veratrum.
·People with spleen and stomach deficiency and yin deficiency and fluid damage should not use it or use it with caution.
During medication, it is necessary to avoid eating cold, raw and cold foods, spicy and greasy foods.
Pregnant and lactating women: If you are pregnant, planning to become pregnant or are lactating, please inform your doctor in time and consult whether Chinese medicine can be used for treatment.
Children: Children’s medication must be carried out under the guidance of a doctor and adult supervision.
Please properly store the medicinal materials and do not give the medicinal materials you use to others.
How to identify and use Sophora flavescens?
·Sophora flavescens is bitter and cold. It enters the heart, liver, stomach, large intestine, and bladder meridians. It has the functions of clearing heat and drying dampness, killing insects, and diuresis. It is used for heat dysentery, blood in stool, jaundice, urine retention, leukorrhea, vaginal swelling, vaginal itching, eczema, wet sores, skin itching, scabies and leprosy; it is used externally to treat trichomoniasis vaginitis and other symptoms. Sophora flavescens is extremely bitter and very cold in nature. It has strong diuretic effects. It is used for damp-heat jaundice, dysentery, leukorrhea, vaginal itching, painful urination, scabies, skin itching, leprosy and trichomoniasis vaginitis, etc.
The bitter and cold nature of Sophora flavescens charcoal is weakened, and the astringency is increased, mainly to stop bleeding. It is used for bloody dysentery, blood in stool and hemorrhoid bleeding, etc.
Medication tips
患者様から最もよく聞かれる質問
The effects and functions of Angelica and Sophora flavescens pills
Danggui and Sophora flavescens pills are composed of Angelica and Sophora flavescens. It has the effects of cooling blood and removing dampness.
It is used for head and face sores, acne lumps, eczema itching, and rosacea redness caused by blood dryness and dampness.
Usage of compound sophora flavescens lotion
Compound sophora flavescens lotion is composed of sophora flavescens, white fresh bark, Kochia scoparia, etc.
It has the effects of clearing heat and detoxifying, drying dampness and relieving itching. It is used to improve symptoms such as excessive vaginal discharge and vulvar cancer itching in women.
Before use, dilute this product with warm water to a concentration of 30%~50%, and then wash the vulva. 1~2 times a day, seven days as a course of treatment.
What gynecological diseases does sophora flavescens tablets mainly treat?
Sophora flavescens tablets are composed of sophora flavescens. It has the effects of clearing heat and drying dampness, killing insects. In gynecological diseases, it can treat vaginal swelling, itching, eczema, wet sores, etc. Oral. 4~6 tablets at a time, 3 times a day.
During the medication period, avoid eating raw, cold, greasy and spicy foods.
Is it normal to feel hot and spicy when sophora flavescens gel is injected?
It is normal to have slight irritation during the use of sophora flavescens gel. If symptoms such as burning sensation and vaginal pain occur, consider the drug Regarding side effects, it is recommended to stop using the drug immediately and rinse the vulva and vagina repeatedly with clean water. If the symptoms are severe, seek medical attention immediately.