知柏地黄丸 – Zhi Bai Di Huang Wan for Menopause & Health Benefits 360 pills*10 boxes

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Prescription: Anemarrhena 40g, Phellodendron 40g, Rehmannia glutinosa 160g, Cornus officinalis (processed) 80g, Peony bark 60g, Chinese yam 80g, Poria 60g, Zexie 60g
Properties: Brown-black water-honey pills, dark-brown small honey pills or large honey pills; sweet with sour and bitter taste.
Processing: Grind the above eight ingredients into fine powder, sieve and mix well. For every 100g of powder, add 35-50g of refined honey and appropriate amount of water to make pills, dry and make water-honey pills; or add 80-110g of refined honey to make small honey pills or large honey pills.
Functions and indications: Nourishes yin and reduces fire. Used for yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine.
Usage and Dosage: Oral, 6g of water-honey pills, 9g of small honey pills, and 1 large honey pill; twice a day.
Specifications Large honey pills weigh 9g each
Storage Sealed.
Excerpt from “Chinese Pharmacopoeia”
Zhibai Dihuang Wan, a Chinese patent medicine. It is composed of Anemarrhena, Phellodendron, Rehmannia glutinosa, Cornus officinalis (processed), Peony Root, Chinese Yam, Poria, and Alisma. It has the effect of nourishing yin and reducing fire. It is used for yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine.
प्रभावहरू
Zhibai Dihuang Wan is a basic prescription for nourishing yin and reducing fire, and is used to treat symptoms such as yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea.
What diseases can Zhibai Dihuang Wan be used to treat?
Yin deficiency and fire, hot flashes and night sweats, slow throat paralysis, tinnitus, and spermatorrhea.
Function: nourishing yin and reducing fire.
Indications: used for yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine.
What symptoms can Zhibai Dihuang Wan be used to relieve?
Congenital deficiency of Yin fluid, or misuse or overuse of warm and dry drugs, Yin fluid depletion, internal disturbance of virtual fire, resulting in Yin deficiency and fire excess, with symptoms of weight loss, hot flashes, night sweats, red cheeks, fever in the five hearts, dry throat and mouth, sore waist and knees, and short and red urine.
Congenital Yin deficiency, or prolonged fever, excessive fatigue, or blood loss and loss of semen, internal generation of virtual fire, disturbance of Yin fluid, unable to store and leak out, resulting in hot flashes and night sweats, with symptoms of hot flashes in the afternoon, bone steaming and fatigue fever, night fever, hot hands and feet, and irritability.
Congenital Yin deficiency or heat damage to body fluid, virtual fire ascends, fumigation and burning of the throat, resulting in chronic throat paralysis, with symptoms of dry throat discomfort, burning, dull pain, itchy throat and dry cough, foreign body sensation, sore waist and knees, and fever in the five hearts; chronic pharyngitis with the above symptoms.
Insufficient kidney essence and qi in the elderly, or excessive sexual intercourse, kidney yin depletion, lack of nourishment to the ears, resulting in tinnitus, with symptoms of tinnitus, dizziness, and weakness in the waist and knees; those with neurological deafness with the above symptoms. Excessive sexual intercourse, indulgence in lust, or unfulfilled fantasies, disturbing the sperm chamber and causing spermatorrhea, with symptoms of spermatorrhea, dizziness, tinnitus, weakness in the waist and knees, and mental depression; those with sexual dysfunction with the above symptoms. What other uses does Zhibai Dihuang Wan have? In addition, there are reports that Zhibai Dihuang Wan is used to treat oral ulcers, menopausal syndrome in women, intermenstrual bleeding, and chronic prostatitis. The most frequently asked questions by patients History tracing Zhibai Dihuang Wan is derived from Shenqi Wan in “Golden Chamber Synopsis”. Qian Yi, a famous doctor in the Song Dynasty, created Dihuang Pills by removing Guizhi and Fuzi from Shenqi Pills based on the physiological characteristics of children’s “pure yang body”. Later generations of doctors created many new prescriptions based on this prescription. For example, Zhibai Dihuang Pills added Zhimu and Huangbai to the Dihuang Pills created by Qian Yi, which enhanced its effect of nourishing yin and clearing heat, and became a classic prescription for nourishing yin and reducing fire.
Ancient Books
According to Qian Yi’s “Children’s Medicine Formulas” in the Song Dynasty, Dihuang Pills are used to treat kidney timidity, aphonia, inability to close fontanelles, lack of spirit, more white in the eyes, and pale complexion.
Explanation of the prescription
The prescription uses Rehmannia glutinosa as the main medicine to nourish yin and kidney, replenish essence and fill marrow. Cornus officinalis and Chinese yam nourish the kidney and consolidate essence, replenish qi and nourish yin, and help Rehmannia glutinosa nourish kidney yin; Zhimu is sweet, cold and moist, clears deficiency heat, and nourishes kidney yin; Huangbai is bitter and cold, relieves deficiency fire, and strengthens true Yin, with cooked Rehmannia root to nourish Yin and reduce fire, both are ministerial drugs. With Poria cocos to strengthen the spleen and drain dampness; Zexie to promote diuresis and clear heat; Cortex Moutan to clear heat and cool blood, the three medicines are used together, and the tonic has purgation, and the tonic is not greasy. All the medicines work together to nourish Yin and reduce fire.
Precautions
· Use with caution in patients with Qi deficiency fever and real heat.
Use with caution in patients with spleen deficiency, loose stools, and Qi stagnation.
Diabetic patients and those with severe chronic diseases such as hypertension, heart disease, liver disease, and kidney disease should take it under the guidance of a physician.
Who is strictly prohibited from using Zhibai Dihuang Wan?
Those who are allergic to this product are prohibited.
Who needs to use Zhibai Dihuang Wan with caution?
People with allergic constitutions should use it with caution.
Can special populations use Zhibai Dihuang Wan?
Pregnant and lactating women: Use with caution. If you are pregnant, planning to become pregnant, or are lactating, please inform your doctor in time and consult to choose the best Treatment plan.
Children: Children should take the medicine under the guidance of a doctor and adult supervision.
What drugs will Zhibai Dihuang Wan interact with?
If this product is used at the same time as other drugs, drug interactions may occur. Therefore, if you are taking other drugs, please consult a doctor before taking the medicine, and inform the doctor of all your diagnosed diseases and treatment plans.
What is the specific use of Zhibai Dihuang Wan?
It is recommended that patients take the medicine under the guidance of a physician.
प्रयोगको लागि निर्देशनहरू
Avoid spicy and greasy food. Those who are allergic to this product are prohibited, and those with allergic constitutions should use it with caution.
What should I do if I miss Zhibai Dihuang Wan?
If you forget to take it once, you should take it immediately when you remember. If the time is close to the next dose, do not take it again, and take the medicine again according to your usual routine. Thousand Never use double the dose at once.
What should I do if I overdose on Zhibai Dihuang Wan?
It is not clear yet.
What are the adverse reactions of Zhibai Dihuang Wan?
It is not clear yet. If you feel any discomfort during medication, please consult a doctor in time. The doctor will judge whether to stop the medication or take necessary measures according to the severity of the adverse reaction.
Under what circumstances should I stop using Zhibai Dihuang Wan immediately?
If the symptoms do not improve or worsen after taking the medicine for about 7 days, it is recommended to stop the medication and observe.
Under what circumstances do I need to go to the hospital as soon as possible?
Those with worsening symptoms such as Yin deficiency and fire need to see a doctor immediately
Medication tips
बिरामीहरू द्वारा प्रायः सोधिने प्रश्नहरू
Should I take the medicine before or after meals?
This product is a tonic Chinese medicine. It is recommended to take it before meals to facilitate absorption.
Precautions during medication
Avoid spicy and greasy food during medication.
Ingredients
Anemarrhena, Phellodendron, Rehmannia glutinosa, Cornus officinalis (processed), Peony Root, Chinese Yam, Poria, Alisma.
Properties
This product is a black-brown concentrated pill with a slight smell, bitter and sour taste; or a black-brown large honey pill or water-honey pill with a sweet taste and bitter and sour taste.
Main effects
Nourishes yin and reduces fire.
Indications
This product is used for yin deficiency and fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urine.
Clinical application and guidelines
1. Li Zhiqing, He Qinghu, Bin Donghua, etc. conducted clinical observations on the treatment of semen liquefaction in kidney yin deficiency type with Zhibai Dihuang Wan and concluded. (Journal of Hunan University of Traditional Chinese Medicine, 2019, 39 (01): 73-76.)
2. Zhang Yuan, Mi Yuanyuan, and He Jing conducted a study on the effects of Zhibai Dihuang Wan on sex hormones and pregnancy in low ovarian reserve function and its mechanism of action and concluded. (World Traditional Chinese Medicine, 2018, 13 (10): 2405-2408.)
3. Wei Xuan conducted clinical observations on Zhibai Dihuang Wan as an auxiliary treatment for chronic periodontitis and concluded. (Guangming Chinese Medicine, 2018, 33(17): 2518-2520.)
निर्दिष्टीकरणहरू
(1) Concentrated pills weigh 1.7g per 10 pills; (2) Large honey pills weigh 9g per pill; (3) Water honey pills weigh about 3g per 30 pills.
Usage and Dosage
Oral. Concentrated pills: 8 pills at a time, 3 times a day; Water honey pills: 6g at a time; Large honey pills: 1 pill at a time, 2 times a day.
Adverse reactions
Not yet clear.
Contraindications
Not yet clear.
Precautions
Not yet clear.
Drug interactions
If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Storage method
Sealed.
Validity period
36 months
Implementation standard
Chinese Pharmacopoeia 2005 Edition Part I.
Identification
1. Take this product and observe under a microscope: Starch granules are triangular, oval or rectangular, with a diameter of 24-40m, and the umbilicus is short, slit-shaped or herringbone-shaped (yam). Irregular branched masses are colorless and dissolve in chloral hydrate solution; hyphae are colorless or light brown, with a diameter of 4-6μm (Poria). The parenchyma is gray-brown to black-brown, and the cells are mostly wrinkled, containing brown nuclei (Rehmannia glutinosa). Calcium oxalate needles are bundled or scattered, 26-110m long (Anemarrhena asphodeloides). Calcium oxalate clusters exist in colorless thin-walled cells, sometimes several are arranged in rows (Paeonia suffruticosa). The epidermal cells of the fruit peel are orange-yellow, polygonal in surface view, and the anticlinal wall is beaded and thickened (Cornus officinalis). The thin-walled cells are round, with elliptical pits, integrated pit groups; the anticlinal wall of the endodermal cells is wavy, thick, lignified, and has sparse fine pores (Alismatis orientalis). The fiber bundles are bright yellow, and the surrounding cells contain calcium oxalate crystals, forming crystal fibers, and the walls of the crystal-containing cells are lignified and thickened (Phellodendron chinense). 2. Take 6g of honey pills of this product and grind them; or take 9g of small or large honey pills and cut them into pieces. Add 15ml of ether, shake for 15 minutes, let stand for 1 hour, filter, evaporate the ether from the filtrate, add 1ml of acetone to the residue to dissolve it, and use it as the test solution. Take another paeonol reference substance and add acetone to make a solution containing 1mg per 1ml as the reference solution. According to the thin layer chromatography method (General Rule 0502), take 101 of each of the above two solutions and spot them on the same silica gel G thin layer plate to make strips, use cyclohexane-ethyl acetate (3:1) as the developing agent, develop, take out, dry, spray with hydrochloric acid acid 5% ferric chloride ethanol solution, and heat until the spots are clearly colored. In the chromatogram of the test product, the same blue-brown stripes appear at the corresponding position of the chromatogram of the reference substance.
3. Take 2g of this product, chop it, add 5ml of methanol, heat and reflux for 15 minutes, filter, take the filtrate, add methanol to make 5ml, as the test solution. Take 0.1g of Phellodendron chinense reference medicinal material and make the reference medicinal material solution in the same way. Take berberine hydrochloride reference substance and add methanol to make a solution containing 0.5mg per 1ml as the reference solution. According to the thin layer chromatography method (General Rule 0502), take 1μl of each of the above three solutions and spot them on the same silica gel G thin layer plate, use toluene-isopropanol ethyl acetate methanol concentrated ammonia test solution (12:3:6:3:1) as the developing agent, place it in a developing cylinder pre-saturated with ammonia vapor, develop, take out, dry, and examine under ultraviolet light (365nm). In the chromatogram of the test product, the same yellow fluorescent spot appears at the corresponding position of the chromatogram of the reference medicinal material and the chromatogram of the reference substance.
Inspection
It should comply with the relevant provisions under the pills (General Rule 0108). Content determination
1. Cornus officinalis:
(1) Determine according to the high performance liquid chromatography method (General Rule 0512).
(2) Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; tetrahydrofuran-methanol-acetonitrile-0.05% phosphoric acid solution (1:4:8:87) is used as mobile phase; column temperature is 40℃; detection wavelength is 236nm. The number of theoretical plates calculated based on the loganin peak should not be less than 4000.
(3) Preparation of reference solution: Take an appropriate amount of loganin reference substance, accurately weigh it, add 50% methanol to make a solution containing 40 per 1ml, and the test solution is obtained. Take the water-honeyed pills of this product, grind them, take 0.7g, and accurately weigh them; or take the small honeyed pills or the large honeyed pills under the weight difference item, cut them into pieces, mix them, and take about 1g and accurately weigh them. Place in a stoppered conical flask, accurately add 25 ml of 50% methanol, seal, weigh, ultrasonically treat (power 250 W, frequency 33 kHz) for 15 minutes, heat and reflux for 1 hour, cool, weigh again, make up the lost weight with 50% methanol, shake well, filter, accurately measure 10 ml of the filtrate, add it to a neutral alumina column (100-200 mesh, 4 g, inner diameter 1 cm), elute with 50 ml of 40% methanol, collect the effluent and eluent, evaporate to dryness, dissolve the residue with 50% methanol, transfer to a 5m volumetric flask, add 50% methanol to the scale, shake well, filter, take the filtrate, and obtain.
(4) Determination method: Accurately aspirate 10 μl of the reference solution and the test solution, inject into the liquid chromatograph, and determine. (5) This product contains Cornus officinalis, calculated as loganin (C17H26O10), which shall not be less than 0.53 mg per 1g of water-honeyed pills; not less than 0.40 mg per 1g of small honeyed pills; and not less than 3.6 mg per large honeyed pill.
2. Paeonia suffruticosa:
(1) Determine according to high performance liquid chromatography (General Rule 0512).
(2) Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler; methanol and water (70:30) is used as mobile phase; the detection wavelength is 274 nm, and the theoretical plate number calculated based on the paeonol peak should not be less than 3500.
(3) Preparation of reference solution: Take an appropriate amount of paeonol reference substance, accurately weigh it, and add methanol to make a solution containing 15 μg per 1ml. (4) Preparation of test solution: Take the honeyed pills of this product, grind them, take 0.4g, and weigh accurately; or take the small honeyed pills or the large honeyed pills under the weight difference item, cut them into pieces, mix them, take 0.5g, and weigh accurately. Place in a stoppered conical flask, accurately add 50ml of 50% methanol, seal it, weigh it, ultrasonically treat it (power 250W, frequency 33kHz) for 45 minutes, let it cool, weigh it again, make up the lost weight with 50% methanol, shake it well, filter it, and take the filtrate.
(5) Determination method: Accurately take 10μl of the reference solution and 20μl of the test solution, inject them into the liquid chromatograph, and determine it.
(6) This product contains peony bark in terms of paeonol (C9H10O3). The content of each gram of honeyed pills shall not be less than 0.80mg; each gram of small honeyed pills shall not be less than 0.55mg; and each gram of large honeyed pills shall not be less than 5.0mg.
Note: Please read the instructions carefully and use under the guidance of a physician.